AZATADINE MALEATE (200 MG)

Product Name: AZATADINE MALEATE (200 MG)
CAS No.: 3978-86-7
Chemical Name: AZATADINE MALEATE (200 MG)
Synonyms: Zadine;idulian;optimine;sch10649;idinedimaleate;azatadinemaleate;Einecs 223-615-8;azatadinedimaleate;AZATADINE MALEATE (200 MG);AZATADINE MALEATE USP/EP/BP
CBNumber: CB3501391
Molecular Formula: C28H30N2O8
Formula Weight: 522.5464
MOL File: 3978-86-7.mol

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AZATADINE MALEATE (200 MG) Property

Melting point:: 152-154°
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White

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Safety

HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29758
Product name: Azatadine (maleate)
Packaging: 50mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 29758
Product name: Azatadine (maleate)
Packaging: 100mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 29758
Product name: Azatadine (maleate)
Packaging: 250mg
Price: $190
Updated: 2024/03/01

Cayman Chemical

Product number: 29758
Product name: Azatadine (maleate)
Packaging: 500mg
Price: $351
Updated: 2024/03/01

TRC

Product number: A802950
Product name: AzatadineDimaleate
Packaging: 500mg
Price: $270
Updated: 2021/12/16

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AZATADINE MALEATE (200 MG) Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Idulian,Unilabo,France,1968

Uses

Antihistaminic.

Definition

ChEBI: The dimaleate salt of azatadine.

Manufacturing Process

Preparation of 4-aza-5-(N-methyl-4-piperidyl)-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene-5-ol: Add 17.4 g of N-methyl-4-chloropiperidine to a stirred mixture containing 3.2 g of magnesium, 20 ml of anhydrous tetrahydrofuran, 1 ml of ethyl bromide and a crystal of iodine. Reflux for two hours, cool to 30-35°C and add a solution of 13 g of 4-aza-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene-5-one in 25 ml of tetrahydrofuran. Stir for five hours, remove the solvent by distillation in vacuum and add 250 ml of ether. Add 100 ml of 10% ammonium chloride solution and extract the mixture with chloroform. Concentrate the chloroform solution to a residue and recrystallize from isopropyl ether obtaining 20 g of the carbinol, MP 173-174°C.
Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene: Heat 5.4 g of the carbinol and 270 g of polyphosphoric acid for 12 hours at 140-170°C. Pour into ice water and make alkaline with sodium hydroxide. Extract with ether. Dry ether solution and concentrate to a residue. Crystallize from isopropyl ether, MP 124-126°C.
Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene dimaleate: To a solution containing 4.3 g of 4-aza- (N-methyl-4-piperidylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene in 55 ml of ethyl acetate, add a solution of 3.45 g of maleic acid dissolved in ethyl acetate. Filter the resulting precipitate and recrystallize the desired product from an ethyl acetate-methanol mixture to yield 4-aza-5-(N-methyl-4- piperidylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene dimaleate, MP 152-154°C.

brand name

Optimine (Schering);Verban.

Therapeutic Function

Antihistaminic

General Description

Azatadine maleate, 6,11-dihydro-11-(l-methyl-4-piperidylidene)-5H-benzo-[5,6]cyclo-hepta(1,2-b]pyridine maleate (1:2) (Optimine), is a potent,long-acting antihistaminic with antiserotonin activity. Inearly testing, azatadine exhibited more than three times thepotency of chiorpheniramine in the isolated guinea pigileum screen and more than seven times the oral potency ofchlorpheniramine in protection of guinea pigs against a doublelethal dose of intravenously administered histamine.

AZATADINE MALEATE (200 MG) Preparation Products And Raw materials

Raw materials

Preparation Products

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AZATADINE MALEATE (200 MG) Suppliers

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View Lastest Price from AZATADINE MALEATE (200 MG) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: AZATADINE MALEATE 3978-86-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: AZATADINE MALEATE 3978-86-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

3978-86-7, AZATADINE MALEATE (200 MG)Related Search:

5-Azacytidine

AZATADINE MALEATE;OPTIMINE;ZADINE

Zadine

11h-benzo(5,6)cyclohepta(1,2-b)pyridine,5,6-dihydro-11-(1-methyl-4-piperidylid

6,11-dihydro-11-(1-methyl-4-piperidylidene)5h-benzo(5,6)cyclohepta(1,2-b)pyr

azatadinedimaleate

5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (2Z)-2-butenedioate (1:2)

Azatadine Maleate(Azatadine dimaleate)

azatadinemaleate

idinedimaleate

idulian

optimine

sch10649

AZATADINE MALEATE (200 MG)

6,11-dihydro-11-(1-methylpiperidin-4-ylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine dimaleate

11H-Benzo(5,6)cyclohepta(1,2-B)pyridine, 5,6-dihydro-11-(1-methyl-4-piperidylidene)-, dimaleate

5H-Benzo(5,6)cyclohepta(1,2-B)pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (Z)-2-butenedioate (1:2)

6,11-Dihydro-11-(1-methyl-4-piperidylidene)5H-benzo(5,6)cyclohepta(1,2-B)pyridine dimaleate

Einecs 223-615-8

AZATADINE MALEATE (200 MG) USP/EP/BP

AZATADINE MALEATE USP/EP/BP

Azatadine Maleate (1045803)

11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine dimaleate

3978-86-7

C20H22N2C4H4O42