O-METHYL-O'-SUCCINYLPOLYETHYLENE GLYCOL& Property

Melting point:

56-60 °C

storage temp. 

−20°C

form 

powder

α-end

methoxy

Ω-end

carboxylic acid

EPA Substance Registry System

Poly(oxy-1,2-ethanediyl), .alpha.-(3-carboxy-1-oxopropyl)-.omega.-methoxy- (31961-02-1)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

F 

3-10-23

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

O-METHYL-O'-SUCCINYLPOLYETHYLENE GLYCOL& Chemical Properties,Usage,Production

Uses

Soluble polymer for solid phase synthesis of peptides 1

Uses

Soluble polymer for solid phase synthesis of imines and β-lactams1; attaching peptides to PEG2,3

Biological Activity

O-Methyl-Oμ-succinylpolyethylene glycol 5μ000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.