N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P

Product Name: N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P
CAS No.: 357965-99-2
Chemical Name: N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P
Synonyms: NOS1-IN-1;NOS-1-IN-1,NOS1 IN 1,NOS1IN1;N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P;Nitric Oxide Synthase, Neuronal Inhibitor I;Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2;Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem;Guanidine, N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitro-, 2,2,2-trifluoroacetate (1:3)
CBNumber: CB3503108
Molecular Formula: C8H21N7O2.3C2HF3O2
Formula Weight: 589.367
MOL File: 357965-99-2.mol

More

Less

N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P Property

storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, soluble
form: powder
color: White to off-white
Water Solubility: water: 1mg/mL
InChI: 1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1
InChIKey: NYWNMNBIORWOSQ-QTPLPEIMSA-N
SMILES: FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.[N+](=O)(N\C(=N\CCC[C@H](N)CNCCN)\N)[O-]

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 490070
Product name: Nitric Oxide Synthase, Neuronal Inhibitor I
Packaging: 5mg
Price: $697
Updated: 2026/04/30

Cayman Chemical

Product number: 20906
Product name: nNOS Inhibitor I
Purity: ≥95%
Packaging: 500μg
Price: $75
Updated: 2026/04/30

Cayman Chemical

Product number: 20906
Product name: nNOS Inhibitor I
Purity: ≥95%
Packaging: 1mg
Price: $134
Updated: 2026/04/30

Cayman Chemical

Product number: 20906
Product name: nNOS Inhibitor I
Purity: ≥95%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 20906
Product name: nNOS Inhibitor I
Purity: ≥95%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

More

Less

N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P Chemical Properties,Usage,Production

Uses

NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP)[2].

Biological Activity

Cell permeable: yes', 'Primary Target
nNOS', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 120 nM against nNOS

IC 50

nNOS: 120 nM (Ki)

References

[1] J M Hah, et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44(16):2667-70. DOI:10.1021/jm0101491
[2] Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65(2):209-17. DOI:10.1002/ana.21555

N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P Suppliers

China 24 Switzerland 1 United States 3 USA 1 Global 29

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13770331960
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1603
Advantage: 59

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 1276242629@qq.com
Country: China
ProdList: 9993
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24960
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4510
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 6000
Advantage: 58

Beijing Boorsen Biotechnology Co., Ltd

Tel: 400-901-9800 18611424007
Email: cis@bioss.com.cn
Country: China
ProdList: 9185
Advantage: 58

357965-99-2, N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]PRelated Search:

Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem

N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P

Nitric Oxide Synthase, Neuronal Inhibitor I

Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2

NOS1-IN-1

NOS-1-IN-1,NOS1 IN 1,NOS1IN1

Guanidine, N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitro-, 2,2,2-trifluoroacetate (1:3)

357965-99-2

C14H24N7O8F9