NANAOMYCIN A

Product Name: NANAOMYCIN A
CAS No.: 52934-83-5
Chemical Name: NANAOMYCIN A
Synonyms: os-3966-a;Nanaomycin;rosanomycina;heptauromycin;(1s-e)-10-dioxo;OS-3966-A; ROSANOMYCINA;1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,;(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid;(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid;Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-
CBNumber: CB3503991
Molecular Formula: C16H14O6
Formula Weight: 302.28
MOL File: 52934-83-5.mol

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NANAOMYCIN A Property

Melting point:: 179°C
Boiling point:: 363.32°C (rough estimate)
Density: 1.2514 (rough estimate)
refractive index: 1.4600 (estimate)
storage temp.: −20°C
solubility: insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic
form: solid
color: Yellow to orange

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Safety

Hazard Codes: T
Risk Statements: 22-24
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: QL6127000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A8191
Product name: NanaomycinA
Packaging: 10mM(in 1mL DMSO)
Price: $340
Updated: 2021/12/16

ApexBio Technology

Product number: A8191
Product name: NanaomycinA
Packaging: 5mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010483
Product name: 1H-NAPHTHO[2,3-C]PYRAN-3-ACETIC ACID, 3,4,5,10-TETRAHYDRO-9-HYDROXY-1-METHYL-5,10-DIOXO-(1S,3R)-
Purity: 95.00%
Packaging: 5MG
Price: $500.38
Updated: 2021/12/16

ApexBio Technology

Product number: A8191
Product name: NanaomycinA
Packaging: 25mg
Price: $1000
Updated: 2021/12/16

ChemScene

Product number: CS-0027820
Product name: NanaomycinA
Purity: ≥98.0%
Packaging: 5mg
Price: $1050
Updated: 2021/12/16

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NANAOMYCIN A Chemical Properties,Usage,Production

Definition

ChEBI: A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis.

Biological Activity

nanaomycin a is a selective inhibitor of dna methyltransferase 3b (dnmt3b) with ic50 value of 500 nm [1].in the biochemical in vitro methylation assay, nanaomycin a showed selective inhibition of dnmt3b but not dnmt1 although it was docked to the catalytic domain of human dnmt1 in a multi-step docking approach. nanaomycin a showed cell viability inhibition in hct116, a549 and hl60 cells with ic50 values of 400 nm, 4100 nm and 800 nm, respectively. it decreased the genomic methylation level of these cells significantly. besides that, nanaomycin a treatment resulted in demethylation of the rassf1a promoter in a549 cells. the demethylation caused by nanaomycin a reactivated the transcription and expression of a silenced tumor suppressor gene [1].

target

DNMT3B

References

[1] kuck d, caulfield t, lyko f, et al. nanaomycin a selectively inhibits dnmt3b and reactivates silenced tumor suppressor genes in human cancer cells. molecular cancer therapeutics, 2010, 9(11): 3015-3023.

NANAOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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NANAOMYCIN A Suppliers

China 20 South Korea 1 Switzerland 1 United States 6 Global 28

Hangzhou Yuhao Chemical Technology Co., Ltd

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52934-83-5, NANAOMYCIN ARelated Search:

Gentamicin sulfate

(1s-e)-10-dioxo

1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,

os-3966-a

rosanomycina

Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-

(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid

(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid

OS-3966-A; ROSANOMYCINA

Nanaomycin

heptauromycin

52934-83-5