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4-AMINOPHENYL-1-PHENETHYLPIPERIDINE

Product Name
4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
CAS No.
21409-26-7
Chemical Name
4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
Synonyms
4-ANPP;Fentanyl Related Compound E;TBC-5487;4-ANPP (CRM);4-ANPP solution;Depropionylfentanyl;Fentanyl Impurity D;Fentanyl Citrate Impurity D;Fentanyl Citrate EP Impurity D;Fentanyl Related CoMpound E CII
CBNumber
CB3506659
Molecular Formula
C19H24N2
Formula Weight
280.41
MOL File
21409-26-7.mol
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4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Property

Melting point:
94-96°C
Boiling point:
172-176 °C(Press: 0.15 Torr)
Density 
1.075±0.06 g/cm3(Predicted)
Flash point:
9°C
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
form 
Off-white solid.
pka
9.03±0.10(Predicted)
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Safety

Risk Statements 
22-36/37/38
Safety Statements 
22-37/39-46
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
HS Code 
29333990
DEA Controlled Substances
CSCN: 8333
CSA SCH: Schedule II
NARC: No
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A-139
Product name
4-ANPP solution
Purity
100?μg/mL in methanol, certified reference material, ampule of 0.5?mL, Cerilliant?
Packaging
0.5ml
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
1269957
Product name
Fentanyl Related Compound E
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10mg
Price
$1380
Updated
2024/03/01
Cayman Chemical
Product number
22700
Product name
4-ANPP (CRM)
Packaging
1mg
Price
$180
Updated
2023/06/20
Cayman Chemical
Product number
18810
Product name
4-ANPP
Packaging
50mg
Price
$1053
Updated
2023/06/20
Cayman Chemical
Product number
18810
Product name
4-ANPP
Packaging
1mg
Price
$71
Updated
2023/06/20
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4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Chemical Properties,Usage,Production

Description

4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids. 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl. It has also been found as an impurity in illicit fentanyl preparations. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Description

4-ANPP (CRM) (Item No. 22700) is a certified reference material that is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl (Item Nos. 22659 | 14719 | ISO60197) from N-phenethyl-4-piperidone (NPP; ). As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl (Item Nos. ISO00128 | ISO60128), butyryl fentanyl (Item Nos. 14728 | 19734), furanyl fentanyl (Item Nos. 18705 | 19633), acrylfentanyl , and fentanyl. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

Pale Yellow Solid

Uses

A 3H-Fentanyl (F274990) metabolite

4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Suppliers

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21409-26-7, 4-AMINOPHENYL-1-PHENETHYLPIPERIDINERelated Search:

FENTANYL 4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Fentanyl citrate Carfentanil Lofentanil Ocfentanil 4-PIPERIDINECARBOXYLIC ACID, 4-[(1-OXOPROPYL)PHENYLAMINO] 4-PIPERIDINECARBOXYLIC ACID, 4-[(1-OXOPROPYL)PHENYLAMINO]-1-(2-PHENYLETHYL), SODIUM SALT N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride Mefentanyl 1-ACETYL-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]-INDOLIN-5-AMINE phenaridine DESPROPIONYL-3-METHYLFENTANYL SALOR-INT L118621-1EA N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N'-(2-METHOXYPHENYL)-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]UREA SALOR-INT L118680-1EA N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]CYCLOPROPYLCARBOXAMIDE N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]-3-PHENYL-(2E)-PROPENAMIDE

  • Fentanyl Related Compound E
  • 4-ANPP solution
  • 4-ANPP (CRM)
  • N-PHENYL-1-(2-PHENYLETHYL) PIPERIDIN-4-AMINE
  • (1-PHENETHYL-PIPERIDIN-4-YL)-PHENYL-AMINE
  • N-Phenyl-1-(2-phenethyl)piperidin-4-amine
  • N-(1-PHENETHYL-PIPERIDIN-4-YL)-ANILINE
  • 4-Piperidinamine, N-phenyl-1-(2-phenylethyl)-
  • N-Phenyl-N’-[1-(2-phenylethyl)]-4-piperidine Discontinued See: A625875
  • N-[1-(2-Phenylethyl)-4-piperidinyl]benzenamine
  • N-Phenyl-1-(2-phenylethyl)-4-piperidinamine
  • Fentanyl Related Compound E CII (10 mg) (N-Phenyl-1-(2-phenylethyl)-4-piperidinamine)
  • 1-Phenethyl-N-phenylpiperidin-4-aMine
  • Depropionylfentanyl
  • N-[1-(2-Phenylethyl)-4-piperidinyl]aniline
  • TBC-5487
  • N-(1-phenyl-piperidin-4-yl)-aniline
  • Fentanyl Related CoMpound E CII
  • 4-ANPP
  • 2-phenyl-1-(2-phenylethyl)-4-piperidinamine
  • 4-Aminophenyl-1-phenethylpiperidine (100 μg/mL in Methanol)
  • 1-(b-Phenethyl)-4-anilinopiperidine
  • Fentanyl Related Compound E CII (N-Phenyl-1-(2-phenylethyl)-4-piperidinamine) (1269957)
  • Fentanyl USP Related Compound E
  • 4-AMinophenyl-1-phenethylpiperidine (Fentanyl IMpurity)
  • Fentanyl Citrate ImpurityⅠ:4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
  • Fentanyl Citrate ImpurityⅠ:4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
  • Fentanyl Impurity D
  • Fentanyl Citrate EP Impurity D
  • Fentanyl Citrate Impurity D
  • Stavudine Impurity 5 (Stavudine EP Impurity E)
  • 21409-26-7
  • Metabolite & Impurities
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics