ChemicalBook > CAS DataBase List > ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

Product Name
ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
CAS No.
304693-64-9
Chemical Name
ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
Synonyms
Ethyl 2-(trifluoromethyl);5-(Ethoxycarbonyl)-2-(trifluoromethyl)pyrimidine;ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;5-PYRIMIDINECARBOXYLIC ACID, 2-(TRIFLUOROMETHYL)-, ETHYL ESTER;Ethyl?2-(trifluoromethyl)pyrimidine-5-carboxylate CAS：304693-64-9;ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH
CBNumber
CB3523533
Molecular Formula
C8H7F3N2O2
Formula Weight
220.15
MOL File
304693-64-9.mol
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ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Property

Melting point:
65 °C
Boiling point:
194℃
Density 
1.344
Flash point:
71℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder
pka
-3.50±0.22(Predicted)
color 
Yellow
InChI
InChI=1S/C8H7F3N2O2/c1-2-15-6(14)5-3-12-7(13-4-5)8(9,10)11/h3-4H,2H2,1H3
InChIKey
LRUCUGOOQHJEQP-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=C(C(OCC)=O)C=N1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
E930603
Product name
Ethyl2-(Trifluoromethyl)pyrimidine-5-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC11106
Product name
Ethyl2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging
5g
Price
$140
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-3-Z8
Product name
Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging
5G
Price
$224
Updated
2021/12/16
AK Scientific
Product number
W5288
Product name
Ethyl2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging
10g
Price
$331
Updated
2021/12/16
Apolloscientific
Product number
PC11106
Product name
Ethyl2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging
25g
Price
$485
Updated
2021/12/16
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ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 2-(Trifluoromethyl)pyrimidine-5-carboxylate is used to prepare NF-κB and AP-1 gene inhibitors.

Synthesis

720-01-4

304693-64-9

Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate (55.7 g) was added to a mixture of 10% palladium-carbon catalyst (0.3 g), ethanol (1000 ml) and N,N-diisopropylethylamine (90 ml) as a starting material. The reaction was shaken under hydrogen atmosphere at 1 atm for 2 hours. After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation. The residue was dissolved in dichloromethane, washed sequentially with ammonium chloride solution and water, dried over anhydrous magnesium sulfate, and the solvent was evaporated to afford the target product, ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, as a light yellow solid (48 g, 100% yield). The structure of the product was confirmed by 1H-NMR (CDCl3) δ 9.42 (2H, s), 4.51 (2H, q), 1.45 (3H, t) and 13C-NMR (CDCl3) δ 162.7,159.4 (2C), 159.3 (q, J=37Hz), 126.3,119.6 (q, J=275Hz), 62.9,. 14.4 Confirmed.

References

[1] Patent: US2004/167142, 2004, A1. Location in patent: Page/Page column 23
[2] Patent: US2013/72470, 2013, A1. Location in patent: Paragraph 0389-0391
[3] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 362
[4] Patent: TW2016/5858, 2016, A. Location in patent: Page/Page column 134
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 1, p. 51 - 55

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Sodium hydride Silica gel Ethanol Diethyl ether Ethyl acetate Dichloromethane Ethyl 3,3-Diethoxypropionate Trifluoroacetamidine

Preparation Products

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ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Suppliers

China 69 India 2 Ukraine 1 United Kingdom 1 United States 9 Global 82
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
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United States
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63687
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Synthonix Inc
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info@synthonix.com
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United States
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6872
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HDH Pharma, Inc.
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catalog@hdhpharma.com
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Bio-Vin Research Laboratories
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Combi-Blocks Inc.
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SynQuest Laboratories, Inc.
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United States
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6871
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62
Matrix Scientific
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United States
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SynInnova Laboratories Inc.
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sales@syninnova.com
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United States
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View Lastest Price from ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE manufacturers

Dideu Industries Group Limited
Product
ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 304693-64-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-07
Career Henan Chemical Co
Product
ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 304693-64-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-08

304693-64-9, ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATERelated Search:

Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID 5-Pyrimidinecarboxylic acid ETHYL 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-METHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-TRIFLUOROMETHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-CYCLOPROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-METHOXYPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-CHLOROPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-BROMOPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-NITROPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-FLUOROPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-PROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-METHYLPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-ETHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-ISOPROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL 4-HYDRAZINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

  • ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
  • 5-PYRIMIDINECARBOXYLIC ACID, 2-(TRIFLUOROMETHYL)-, ETHYL ESTER
  • 5-(Ethoxycarbonyl)-2-(trifluoromethyl)pyrimidine
  • Ethyl 2-(trifluoromethyl)
  • ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH
  • Ethyl?2-(trifluoromethyl)pyrimidine-5-carboxylate CAS：304693-64-9
  • 304693-64-9
  • pyrimidine
  • Fluorine series