PFE-360

Product Name: PFE-360
CAS No.: 1527475-61-1
Chemical Name: PFE-360
Synonyms: PFE-360;PF-06685360;1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-;PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2
CBNumber: CB35419811
Molecular Formula: C16H16N6O
Formula Weight: 308.34
MOL File: 1527475-61-1.mol

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PFE-360 Property

storage temp.: room temp
solubility: DMSO: 2 mg/mL, clear
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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PFE-360 Chemical Properties,Usage,Production

Description

PFE-360 (PF-06685360) is a poten and elective inhibitor of LRRK2 kinase.

in vitro

PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment potently decreases the LRRK2-pSer935/total LRRK2 ratio, with no significant adverse effects.
animal Model: Female Sprague Dawley rats (NTac:SD) weighed 225-250 g.
Dosage: 4 mg/kg and 7.5 mg/kg (pharmacokinetics and pharmacodynamics).
Administration: Orally BID for 10-12 weeks.
Result: The LRRK2-pSer935/total LRRK2 ratio was significantly decreased at both 1 h and 12 h after dosing.
The terminal bodyweights exhibited no significant changes.

PFE-360 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFE-360 Suppliers

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1527475-61-1, PFE-360Related Search:

PFE-360

PF-06685360

1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-

PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2

1527475-61-1