ChemicalBook > CAS DataBase List > KL-1333

KL-1333

Product Name: KL-1333
CAS No.: 1800405-30-4
Chemical Name: KL-1333
Synonyms: KL-1333;Napazimone;NQO1 ACTIVATOR 1;KL1333, 10 mM in DMSO;Napazimone intermediate;KL-1333(NQO1 activator 1);2-Isopropyl-3H-naphtho[1,2-d]imidazole-4,5-dione;2-(1-Methylethyl)-3H-naphth[1,2-d]imidazole-4,5-dione;3H-Naphth[1,2-d]imidazole-4,5-dione, 2-(1-methylethyl)-;2-(propan-2-yl)-1H,4H,5H-naphtho[1,2-d]imidazole-4,5-dione
CBNumber: CB35424910
Molecular Formula: C14H12N2O2
Formula Weight: 240.26
MOL File: 1800405-30-4.mol

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KL-1333 Property

Boiling point:: 517.3±19.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (1040.54 mM)
pka: 8.58±0.20(Predicted)
form: Solid
color: Reddish brown to red
InChI: InChI=1S/C14H12N2O2/c1-7(2)14-15-10-8-5-3-4-6-9(8)12(17)13(18)11(10)16-14/h3-7H,1-2H3,(H,15,16)
InChIKey: AJFWITSBVLLDCC-UHFFFAOYSA-N
SMILES: C1(C(C)C)NC2C(=O)C(=O)C3=C(C=2N=1)C=CC=C3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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KL-1333 Chemical Properties,Usage,Production

Uses

KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures[1][2].

References

[1] Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018;9:552. Published 2018 Jul 5. DOI:10.3389/fneur.2018.00552
[2] Lee HS, et al. KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures. Biomed Pharmacother. 2020;126:110068. DOI:10.1016/j.biopha.2020.110068

KL-1333 Preparation Products And Raw materials

Raw materials

Preparation Products

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1800405-30-4, KL-1333Related Search:

NQO1 ACTIVATOR 1

KL-1333

3H-Naphth[1,2-d]imidazole-4,5-dione, 2-(1-methylethyl)-

2-(1-Methylethyl)-3H-naphth[1,2-d]imidazole-4,5-dione

KL-1333(NQO1 activator 1)

Mitochondrial Metabolism,KL 1333,KL1333,Inhibitor,inhibit,KL-1333

2-Isopropyl-3H-naphtho[1,2-d]imidazole-4,5-dione

2-(propan-2-yl)-1H,4H,5H-naphtho[1,2-d]imidazole-4,5-dione

KL1333, 10 mM in DMSO

Napazimone

Napazimone intermediate

1800405-30-4