CDK8-IN-1

Product Name: CDK8-IN-1
CAS No.: 1629633-48-2
Chemical Name: CDK8-IN-1
Synonyms: CDK8-IN-1;CDK8-IN-16;CDK8-IN-1, 10 mM in DMSO;CDK8IN1,CDK-8-IN-1,CDK8 IN 1;1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)-
CBNumber: CB35540351
Molecular Formula: C11H8F3N3O
Formula Weight: 255.2
MOL File: 1629633-48-2.mol

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CDK8-IN-1 Property

Boiling point:: 406.2±45.0 °C(Predicted)
Density: 1.429±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 12.46±0.50(Predicted)
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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CDK8-IN-1 Chemical Properties,Usage,Production

Description

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

References

[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

CDK8-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK8-IN-1 Suppliers

CHINA 12 United States 2 Global 14

TargetMol Chemicals Inc.

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Nantong QuanYi Biotechnology Co., Ltd

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1629633-48-2, CDK8-IN-1Related Search:

CDK8-IN-1

CDK8-IN-16

CDK8IN1,CDK-8-IN-1,CDK8 IN 1

1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)-

CDK8-IN-1, 10 mM in DMSO

1629633-48-2