ChemicalBook > CAS DataBase List > Methyl (4-bromobenzoyl)-L-cysteinate
Methyl (4-bromobenzoyl)-L-cysteinate
- Product Name
- Methyl (4-bromobenzoyl)-L-cysteinate
- CAS No.
- 1947408-74-3
- Chemical Name
- Methyl (4-bromobenzoyl)-L-cysteinate
- Synonyms
- Methyl (4-bromobenzoyl)-L-cysteinate;L-Cysteine, N-(4-bromobenzoyl)-, methyl ester;pharmacophore,inhibit,Cysteine thiol probe,products,enone-based,chromophore,thiol-based,electrophilic,Inhibitor,l-cystine,Natural
- CBNumber
- CB35542274
- Molecular Formula
- C11H12BrNO3S
- Formula Weight
- 318.19
- MOL File
- 1947408-74-3.mol
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Methyl (4-bromobenzoyl)-L-cysteinate Property
- Boiling point:
- 465.2±45.0 °C(Predicted)
- Density
- 1.491±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 250 mg/mL (785.69 mM)
- pka
- 9.05±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 907243
- Product name
- Methyl (4-bromobenzoyl)-L-cysteinate
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $346
- Updated
- 2023/06/20
DC Chemicals
- Product number
- 012836
- Product name
- Cysteinethiolprobe
- Packaging
- 003
- Price
- $1700
- Updated
- 2021/12/16
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Methyl (4-bromobenzoyl)-L-cysteinate Chemical Properties,Usage,Production
Uses
Methyl (4-bromobenzoyl)-L-cysteinate is a chemoselective thiol probe for detection of electrophilic metabolites. As it is often difficult to isolate low-abundance natural products from extracts, metabolities with bioactivity or therapeutic potential may be missed. Castro-Falcón, et al developed a reactivity-guided approach using thiolate probes to discover electrophilic natural products - a cysteine-based probe and thiophenol-based probe. Both consist of
- A chemoselective reagent for covalent reactivity with a pharmacophore,
- A conspicuous UV/VIS or mass spectrometric (MS) tag,
- A linker between the tag and reagent. Methyl (4-bromobenzoyl)-L-cysteinate contains a bromine MS tag and phenyl bromide UV tag that was demonstrated to chemoselectively label enone-, β-lactam-, and β-lactone-based natural products.
Complementarily, a thiophenol probe (cat# 125237) with a chlorine MS tag and phenyl chloride UV tag labeled epoxide-based natural products. These probes can be used in diverse extracts (bacterial, fungal, plant) to chemically faciliate access to high-value metabolites.
Methyl (4-bromobenzoyl)-L-cysteinate Preparation Products And Raw materials
Raw materials
Preparation Products
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