Dual Specificity Protein Phosphatase 1/6 Inhibitor

Product Name: Dual Specificity Protein Phosphatase 1/6 Inhibitor
CAS No.: 15982-84-0
Chemical Name: Dual Specificity Protein Phosphatase 1/6 Inhibitor
Synonyms: NSC 150117;(E/Z)-BCI (NSC150117);(E/Z)-BCI, 10 mM in DMSO;(E/Z)-BCI(DUSP6 inhibitor);Dual Specificity Protein Phosphatase 1/6 Inhibitor;Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI;2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-;NSC-150117,ROS,death,LPS,(E/Z)-BCI,gastric cancer,anti-inflammatory,NF-κB,inhibit,Inhibitor,(E/Z) BCI,Nrf2,(E/Z)BCI,Apoptosis,ERK,Phosphatase,DUSP6,NSC150117
CBNumber: CB35544728
Molecular Formula: C22H23NO
Formula Weight: 317.42
MOL File: 15982-84-0.mol

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Dual Specificity Protein Phosphatase 1/6 Inhibitor Property

Boiling point:: 484.6±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO: 63 mg/mL (198.48 mM);Ethanol: 20 mg/mL (63.01 mM)
form: solid
pka: 7.74±0.20(Predicted)
color: yellow
Water Solubility: Water: Insoluble

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Safety

HS Code: 2922390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0086
Product name: BCI
Purity: 98%
Packaging: 1mg
Price: $211
Updated: 2021/12/16

Apolloscientific

Product number: BISN0086
Product name: BCI
Purity: 98%
Packaging: 5mg
Price: $385
Updated: 2021/12/16

Apolloscientific

Product number: BISN0086
Product name: BCI
Purity: 98%
Packaging: 10mg
Price: $617
Updated: 2021/12/16

DC Chemicals

Product number: 012534
Product name: (E/Z)-BCI(DUSP6inhibitor)
Packaging: 003
Price: $1900
Updated: 2021/12/16

Ambeed

Product number: A1145656
Product name: 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
Purity: 98%
Packaging: 100mg
Price: $286
Updated: 2021/12/16

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Dual Specificity Protein Phosphatase 1/6 Inhibitor Chemical Properties,Usage,Production

Uses

(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway[1].

in vivo

(E/Z)-BCI hydrochloride (35 mg/kg; intraperitoneal injection; every 7 days; for four weeks; female BALB/c nude mice) treatment enhances cisplatin efficacy in PDX models^[2].

Animal Model:	Patient-derived xenograft (PDX) models (4-5-week-old female BALB/c nude mice)^[2]
Dosage:	35 mg/kg
Administration:	Intraperitoneal injection; every 7 days; for four weeks
Result:	Tumor weights in the PDX models treated plus CDDP were significantly suppressed compared with tumors from PDX model mice treated with either agent alone.

storage

Store at +4°C

References

[1] Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681. DOI:10.1007/s10753-018-0924-2
[2] Wu QN,et al. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance. Cancer Lett. 2018 Jan 1;412:243-255. DOI:10.1016/j.canlet.2017.10.007

Dual Specificity Protein Phosphatase 1/6 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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Dual Specificity Protein Phosphatase 1/6 Inhibitor Suppliers

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15982-84-0, Dual Specificity Protein Phosphatase 1/6 InhibitorRelated Search:

Dual Specificity Protein Phosphatase 1/6 Inhibitor

NSC 150117

(E/Z)-BCI (NSC150117)

1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-

(E/Z)-BCI(DUSP6 inhibitor)

2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one

NSC-150117,ROS,death,LPS,(E/Z)-BCI,gastric cancer,anti-inflammatory,NF-κB,inhibit,Inhibitor,(E/Z) BCI,Nrf2,(E/Z)BCI,Apoptosis,ERK,Phosphatase,DUSP6,NSC150117

(E/Z)-BCI, 10 mM in DMSO

Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI

15982-84-0