Tetraacetylphytosphingosine
- Product Name
- Tetraacetylphytosphingosine
- CAS No.
- 13018-48-9
- Chemical Name
- Tetraacetylphytosphingosine
- Synonyms
- TETRAACETYLPHYTOSPHINGOSINE;Tetraacetylphytosphingosine >Tetraacetyl-D-ribo-Phytosphingosine;Tetraacetylphytosphingosine >=98% (HPLC);Acetamide, N-[(1S,2S,3R)-2,3-bis(acetyloxy)-1-[(acetyloxy)methyl]heptadecyl]-
- CBNumber
- CB35550091
- Molecular Formula
- C26H47NO7
- Formula Weight
- 485.65
- MOL File
- 13018-48-9.mol
Tetraacetylphytosphingosine Property
- Melting point:
- 46 °C
- Boiling point:
- 594.3±50.0 °C(Predicted)
- Density
- 1.021±0.06 g/cm3(Predicted)
- pka
- 14.72±0.46(Predicted)
- InChIKey
- SGTYQWGEVAMVKB-NXCFDTQHSA-N
- SMILES
- C(N[C@@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)CCCCCCCCCCCCCC)(=O)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
Tetraacetylphytosphingosine Chemical Properties,Usage,Production
Description
Tetraacetylphytosphingosine (TAPS) is a sphingolipid metabolite produced by Wickerhamomyces ciferrii (also known as Hansenula ciferrii). It exerts an inhibitory action on angiogenesis through inhibition of the mitogen-activated protein kinase (MAPK) pathway and intracellular calcium increase. Therefore, TAPS was suggested as a potential treatment for angiogenesis related disorders such as arthritis, cancer and psoriasis.
Biological Activity
Tetraacetylphytosphingosine was found to induce apoptosis in HaCaT human keratinocyte cells. In addition, it was demonstrated that TAPS synergistically increases UVB-induced apoptosis via caspase activation by regulating the level of pro-apoptotic Bax and anti-apoptotic Bcl-2 in HaCaT cells.
Tetraacetylphytosphingosine Preparation Products And Raw materials
Raw materials
Preparation Products
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