ChemicalBook > CAS DataBase List > ADH-503

ADH-503

Product Name
ADH-503
CAS No.
2055362-74-6
Chemical Name
ADH-503
Synonyms
ADH503;ADH 503;ADH-503;ADH-503 (GB1275);ADH-503;ADH503;ADH 503;ADH-503, 10 mM in DMSO;ADH-503 (GB1275) ，S0525;(Z)-Leukadherin-1 choline;ADH-503 [(Z)-Leukadherin-1 choline;ADH-503 - Leukadherin-1 choline salt
CBNumber
CB35582357
Molecular Formula
C27H29N2O5S2+
Formula Weight
525.66
MOL File
2055362-74-6.mol
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ADH-503 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 21.43 mg/mL (40.85 mM)
form 
Solid
color 
Brown to reddish brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0113500
Product name
ADH-503
Purity
98.04%
Packaging
5mg
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-0113500
Product name
ADH-503
Purity
98.04%
Packaging
10mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0113500
Product name
ADH-503
Purity
98.04%
Packaging
50mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0113500
Product name
ADH-503
Purity
98.04%
Packaging
100mg
Price
$350
Updated
2021/12/16
Ambeed
Product number
A1193403
Product name
2-Hydroxy-N,N,N-trimethylethan-1-aminium(Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate
Purity
98%
Packaging
5mg
Price
$43
Updated
2021/12/16
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ADH-503 Chemical Properties,Usage,Production

Uses

ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].

in vivo

ADH-503 ((Z)-Leukadherin-1 choline; oral gavage; 30, 60, or 120 mg/kg; twice a day for 60 days) delayes tumor progression, leading to a significantly decreased tumor burden in time-point analysis and improved overall survival[1].
ADH-503 (oral gavage; 30, 100 mg/kg; twice a day; on days 1 and 5) has the mean half-life of 4.68 and 3.95 hours, a maximum concentration of 1716 and 2594 ng/mL and AUC0-t in the plasma of 6950 and 13962 ng.h/mL at 30 and 100 mg/kg dosing, respectively[1].

Animal Model:KPC mice [p48-CRE/Lox-stop-Lox(LSL)-KrasG12D/p53flox/flox][1]
Dosage:30, 60, or 120 mg/kg
Administration:Oral gavage; 60 days
Result:Delayed tumor progression, leading to a significantly decreased tumor burden in time-point analysis and improved overall survival.
Animal Model:Male rats[1]
Dosage:30, 100 mg/kg (Pharmacokinetic Analysis)
Administration:Oral gavage twice a day; on days 1 and 5
Result:Had the mean half-life of 4.68 and 3.95 hours, a maximum concentration of 1716 and 2594 ng/mL and AUC0-t in the plasma of 6950 and 13962 ng.h/mL at 30 and 100 mg/kg dosing, respectively.

References

[1] Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11(499). DOI:10.1126/scitranslmed.aau9240

ADH-503 Preparation Products And Raw materials

Raw materials

Preparation Products

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ADH-503 Suppliers

China 33 United States 6 Global 39
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
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65
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
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60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4827
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
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Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
9697
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58

2055362-74-6, ADH-503Related Search:


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  • 2-Hydroxy-N,N,N-trimethylethan-1-aminium (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate
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  • ADH-503 (GB1275) ，S0525
  • 2055362-74-6