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Abemaciclib Metabolites M2

Product Name
Abemaciclib Metabolites M2
CAS No.
1231930-57-6
Chemical Name
Abemaciclib Metabolites M2
Synonyms
LSN2839567;Des-Et-Abemaciclib;Abemaciclib Impurity 41;Abemaciclib Impurity 44;Abemaciclib Impurity 11;Abemaciclib Impurity 43;Abemaciclib Impurity 42;Abemaciclib M2 Metabolite;Abemaciclib metabolite M2;Abemaciclib Metabolites M2
CBNumber
CB35821258
Molecular Formula
C25H28F2N8
Formula Weight
478.54
MOL File
1231930-57-6.mol
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Abemaciclib Metabolites M2 Property

Boiling point:
690.9±65.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.01±0.10(Predicted)
form 
Solid
color 
Light yellow to yellow
InChIKey
IXGZDCRFGCEEBU-UHFFFAOYSA-N
SMILES
C1(NC2=NC=C(CN3CCNCC3)C=C2)=NC=C(F)C(C2C=C3N(C(C)C)C(C)=NC3=C(F)C=2)=N1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0096557
Product name
AbemaciclibmetaboliteM2
Purity
99.82%
Packaging
1mg
Price
$320
Updated
2021/12/16
ChemScene
Product number
CS-0096557
Product name
AbemaciclibmetaboliteM2
Purity
99.82%
Packaging
5mg
Price
$960
Updated
2021/12/16
ChemScene
Product number
CS-0096557
Product name
AbemaciclibmetaboliteM2
Purity
99.82%
Packaging
10mg
Price
$1600
Updated
2021/12/16
AK Scientific
Product number
4210DP
Product name
AbemaciclibMetabolitesM2
Packaging
1g
Price
$2692
Updated
2021/12/16
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Abemaciclib Metabolites M2 Chemical Properties,Usage,Production

Uses

Des-Et-Abemaciclib is an impurity of Abemaciclib (A115153) is a potent and selective inhibitor of cyclin-dependent kinases, CDK4 and CDK6, as a method to inhibit the proliferation of cancer cells.

in vivo

Abemaciclib metabolite M2 (LSN2839567) is bound to plasma proteins in rat, dog and human (83-92%), lower than Abemaciclib (95-99%)[2].
? Abemaciclib metabolite M2 is the most prominent (active and major) plasma metabolites in human[2].

IC 50

CDK4: 1.2 nM (IC50); CDK6: 1.3 nM (IC50)

Abemaciclib Metabolites M2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Abemaciclib Metabolites M2 Suppliers

China 41 India 2 United States 4 Global 47
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 0086-15250997978
Fax
025-58362220
Email
sale@njxizebio.com
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China
ProdList
4855
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55
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
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64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
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65
Shandong Zhonghan Pharmaceutical Co.,Ltd.
Tel
19862069201
Email
3844950497@qq.com
Country
China
ProdList
289
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Hubei Yangxin Medical Technology Co., Ltd.
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15374522761
Fax
QQ:2853117752
Email
3003392093@qq.com
Country
China
ProdList
10000
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55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
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58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd.
Tel
020-89854820
Email
sales@jzpharma.cn
Country
China
ProdList
1487
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58
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View Lastest Price from Abemaciclib Metabolites M2 manufacturers

Moxin Chemicals
Product
Abemaciclib Nitroso Impurity 43 1231930-57-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
99%+ HPLC
Supply Ability
1000
Release date
2025-07-18
Moxin Chemicals
Product
Abemaciclib Impurity 43 1231930-57-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
10000
Release date
2025-03-05

1231930-57-6, Abemaciclib Metabolites M2Related Search:


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  • 1231930-57-6
  • C25H28F2N8