TD-0212

Product Name: TD-0212
CAS No.: 1073549-10-6
Chemical Name: TD-0212
Synonyms: TD-0212;TD0212,TD 0212;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-ethoxy-4-ethyl-5-[[[(2S)-2-mercapto-4-methyl-1-oxopentyl]amino]methyl]-1H-imidazol-1-yl]methyl]-3'-fluoro-
CBNumber: CB35821324
Molecular Formula: C28H34FN3O4S
Formula Weight: 527.65
MOL File: 1073549-10-6.mol

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Hazard and Precautionary Statements (GHS)

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TD-0212 Chemical Properties,Usage,Production

Description

TD-0212 is a potent, selective and orally active, dual AT1 antagonist/NEP inhibitor (ARNI) with At1 pKi-8.9 and NEP pIC50 = 9.2. TD-0212 produced blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors. TD-0212 therefore provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition

Uses

TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

in vivo

TD-0212 (compound 35) produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and –independent hypertension^[1].

References

[1] McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91. DOI:10.1021/acsmedchemlett.8b00462

TD-0212 Preparation Products And Raw materials

Raw materials

Preparation Products

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TD-0212 Suppliers

China 6 United States 1 Global 7

Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Nanjing Shizhou Biology Technology Co.,Ltd

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TargetMol Chemicals Inc.

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Biosynth Biological Technology (Suzhou) Co Ltd

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Adooq Bioscience LLC

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1073549-10-6, TD-0212Related Search:

TD-0212

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-ethoxy-4-ethyl-5-[[[(2S)-2-mercapto-4-methyl-1-oxopentyl]amino]methyl]-1H-imidazol-1-yl]methyl]-3'-fluoro-

TD0212,TD 0212

1073549-10-6

C28H34FN3O4S