ChemicalBook > CAS DataBase List > 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
- Product Name
- 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
- CAS No.
- 2270879-17-7
- Chemical Name
- 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
- Synonyms
- NVP-RXI570;BRM/BRG1 ATP Inhibitor-1, 10 mM in DMSO;1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea;3-[3-(difluoromethyl)-1,2-thiazol-5-yl]-1-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea;Urea, N-[3-(difluoromethyl)-5-isothiazolyl]-N'-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-;BRM/BRG1 ATP Inhibitor 1,Epigenetic Reader Domain,ATPase inhibitor,BRM/BRG-1 ATP Inhibitor-1,anticancer,BRM/BRG1 ATP Inhibitor-1,(BRG1)/SMARCA4,dual inhibitor,Inhibitor,inhibit,(BRM)/SMARCA2,BRM/BRG1 ATP Inhibitor1
- CBNumber
- CB35832995
- Molecular Formula
- C11H9F3N4O2S
- Formula Weight
- 318.27
- MOL File
- 2270879-17-7.mol
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1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Property
- Boiling point:
- 333.4±42.0 °C(Predicted)
- Density
- 1.659±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 11.76±0.70(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3545
- Product name
- NVP-RXI570
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $99
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML3545
- Product name
- NVP-RXI570
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $399
- Updated
- 2024/03/01
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1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Chemical Properties,Usage,Production
Biological Activity
NVP-RXI570 is an orally active, potent, and selective allosteric dual inhibitor of BRM ((SMARCA2) and BRG1 (SMARCA4) th at th at downregulates BRM-dependent gene expression. NVP-RXI570 exhibits antiproliferative activity in a BRG1 mutant-lung-tumor xenograft model.
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
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