ChemicalBook > CAS DataBase List > 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid

6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid

Product Name
6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid
CAS No.
37972-69-3
Chemical Name
6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid
Synonyms
6-Carboxy-3(2H)-pyridazinone;3-hydroxypyridazine-6-car...;1,6-dihydro-6-ox-3-darbazinate;6-Hydroxy-3-pyridazinecarboxylic acid;6-oxo-1H-pyridazine-3-carboxylic acid;4-hydroxypyriMidine-2-carboxylic acid;6-hydroxy-pyridazine-3-carboxylic acid;6-keto-1H-pyridazine-3-carboxylic acid;6-Hydroxypyridazine-3-carboxylic acid 98%;6-Oxo-1,6-dihydropyridazine-3-carboxylic acid
CBNumber
CB3588824
Molecular Formula
C5H4N2O3
Formula Weight
140.1
MOL File
37972-69-3.mol
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6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Property

Melting point:
246 °C
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-2.86±0.20(Predicted)
Appearance
White to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H953743
Product name
6-Hydroxypyridazine-3-carboxylicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H29-1-08
Product name
6-Carboxy-3(2H)-pyridazinone
Purity
95%
Packaging
1g
Price
$55
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
H12271
Product name
6-Hydroxypyridazine-3-carboxylicacid
Purity
95%
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
057936
Product name
6-Hydroxypyridazine-3-carboxylic acid
Purity
98%
Packaging
1g
Price
$12
Updated
2021/12/16
SynQuest Laboratories
Product number
4H29-1-08
Product name
6-Carboxy-3(2H)-pyridazinone
Purity
95%
Packaging
250mg
Price
$15
Updated
2021/12/16
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6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Chemical Properties,Usage,Production

Uses

6-Hydroxypyridazine-3-carboxylic acid is a carboxylic acid derivative and can be used as an intermediate in organic synthesis.

Synthesis

27372-38-9

37972-69-3

The general procedure for the synthesis of 6-hydroxypyridazine-3-carboxylic acid from 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid was as follows: to a solution of 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid (2.50 g, 17.59 mmol) in toluene (44 mL) was added sequentially copper acetate (450 mg, 2.48 mmol), sodium carbonate ( 7.01 g, 66.14 mmol) and pyridine (4.4 mL). The reaction mixture was stirred and mixed at room temperature, then warmed to 100 °C and stirred continuously for 16 hours. After completion of the reaction, the insoluble solid was removed by filtration and the filtrate was concentrated under reduced pressure to afford 6-oxo-1,6-dihydropyridazine-3-carboxylic acid as an off-white solid (1.80 g, 73% yield). Mass spectrometry result: m/z = 177.0 [M + H]+.

References

[1] European Journal of Organic Chemistry, 2013, # 27, p. 6130 - 6136
[2] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 1225; 1226
[3] Patent: CN106187910, 2016, A. Location in patent: Paragraph 0120; 0121
[4] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 598 - 611

6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Suppliers

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View Lastest Price from 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid manufacturers

Shanghai Rlavie Technology Co ltd
Product
6-Hydroxypyridazine-3-carboxylic acid 37972-69-3
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%minHPLC
Supply Ability
50kgs/month
Release date
2021-11-13
Career Henan Chemical Co
Product
6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE 37972-69-3
Price
US $0.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
500kg
Release date
2019-07-05

37972-69-3, 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacidRelated Search:

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER METHYL 6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLATE 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid 6-Methoxypyridazine-3-carboxylic acid Methyl 4,6-dihydroxypyridazine-3-carboxylate 6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLIC ACID MONOHYDRATE 3-Pyridazinecarboxylic acid Pyrazine METHYL 1-(2,4-DICHLOROPHENYL)-4-HYDROXY-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE METHYL 4-HYDROXY-1-(4-METHYLPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE METHYL 4-CHLORO-6-OXO-1-PHENYL-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE METHYL 4-CHLORO-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLIC ACID METHYL 4-CHLORO-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE METHYL 4-[(2-METHOXY-2-OXOETHYL)SULFANYL]-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

  • 6-Hydroxy-3-pyridazinecarboxylic acid monohydrate
  • 6-Hydroxy-3-pyridazinecarboxylic acid
  • 2,3-DIHYDRO-3-OXOPYRIDAZIN-6-CARBOXYLIC ACID, MONOHYDRATE
  • 6-Oxo-1,6-dihydropyridazine-3-carboxylic acid
  • 3-hydroxypyridazine-6-car...
  • 6-oxo-1,6-dihydropyridazine-3-carboxylic acid(SALTDATA: FREE)
  • 4-hydroxypyriMidine-2-carboxylic acid
  • 6-oxo-1H-pyridazine-3-carboxylic acid
  • 6-keto-1H-pyridazine-3-carboxylic acid
  • 6-hydroxy-pyridazine-3-carboxylic acid
  • 6-Carboxy-3(2H)-pyridazinone
  • 6-Hydroxypyridazine-3-carboxylic acid 98%
  • 1,6-Dihydro-6-oxo-3-pyridazinecarboxylic acid
  • 1,6-dihydro-6-ox-3-darbazinate
  • 3-Pyridazinecarboxylic acid, 1,6-dihydro-6-oxo-
  • 37972-69-3
  • pyridazine
  • Pyridazine series