ChemicalBook > CAS DataBase List > (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one

Product Name
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
CAS No.
139893-81-5
Chemical Name
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
Synonyms
(1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one;Edoxaban Impurity 80;6-Oxabicyclo[3.2.1]octan-7-one, 4-bromo-, (1S-exo)- (9CI);(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneQ: What is (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Q: What is the CAS Number of (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
CBNumber
CB35925598
Molecular Formula
C7H9BrO2
Formula Weight
205.05
MOL File
139893-81-5.mol
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(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Property

Boiling point:
324.2±25.0 °C(Predicted)
Density 
1.642±0.06 g/cm3(Predicted)
InChI
InChI=1/C7H9BrO2/c8-5-2-1-4-3-6(5)10-7(4)9/h4-6H,1-3H2/t4-,5?,6?/s3
InChIKey
HIEDNXSBEYNHJB-OGAAFCRYNA-N
SMILES
[C@]12([H])CC(OC1=O)C(Br)CC2 |&1:0,r|
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Hazard and Precautionary Statements (GHS)

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(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Chemical Properties,Usage,Production

Uses

Used as Edoxaban impurity.

Synthesis

(1S)-Cyclohex-3-ene-1-carboxylic acid (II) (5 g) was dissolved in dichloromethane (25 mL). To this solution, N-bromosuccinimide (1.1 mole) was added at room temperature. In two lots, calcium oxide (0.25 mole) was charged to the Suspension. The reaction mixture was stirred at 20 to 25°C for 1 hour and filtered. The bed was washed with dichloromethane (10 mL). The washings were combined with the filtrate, and the solvent was recovered under vacuum at 35 to 40 °C. Deionized water (50 mL) was charged to the solid, heated to 50 °C, stirred for 10 minutes, and filtered. The bed was washed with deionized water (10 mL) and suction dried. The solid was dried under vacuum at 45-50 °C to get (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one. Yield: 61%

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Suppliers

FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd
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25-8690-7345 18651693585
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zfx@farmasino.com
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China
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Jinan Chenghui Shuangda biological Co., LTD
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0531-58897003 15550412551
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0531-58897003
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market@jnchsd.com
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Shanghai Kewel Chemical Co., Ltd.
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021-64609169 18901607656
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021-64609160
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greensnown@163.com
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China
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9906
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Anqing CHICO Pharmaceutical Co., Ltd.
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13585175604
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+86-25-52261140
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sales@chicopharm.com
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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028-83379370 13880556291
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028-87747383
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tcy@tcypharm.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ:65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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CHENGHUI PHARMACEUTICAL GROUP LTD
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0531-58897070 15254140813
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0531-58897046
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SHANGHAI FDC-CHEMICAL CO.,LTD
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021-61469567 13482353728
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021-61161605
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sales@fdc-chemical.com
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China
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Wuhan Dingxintong Pharmaceutical Co. , Ltd.
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027-52344656 15871722230
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2796190295
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15871722230@163.com
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China
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QUALITY CONTROL SOLUTIONS LTD.
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0755-66853366; 13670046396
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ORDERS@QCSRM.COM
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China
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24342
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139893-81-5, (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneRelated Search:


  • 6-Oxabicyclo[3.2.1]octan-7-one, 4-bromo-, (1S-exo)- (9CI)
  • (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one
  • Edoxaban Impurity 80
  • (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneQ: What is (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Q: What is the CAS Number of (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
  • 139893-81-5