E3 Ligase Ligand-Linker Conjugates 58

Product Name: E3 Ligase Ligand-Linker Conjugates 58
CAS No.: 2172820-14-1
Chemical Name: E3 Ligase Ligand-Linker Conjugates 58
Synonyms: VH032-PEG5-COOH;VH 032 amide-PEG5-acid;(S,R,S)-AHPC-PEG5-COOH;VHL Ligand-Linker Conjugates 16;E3 Ligase Ligand-Linker Conjugates 58;L-Prolinamide, N-(18-carboxy-1-oxo-4,7,10,13,16-pentaoxaoctadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosan-1-oic acid;1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
CBNumber: CB36127045
Molecular Formula: C36H54N4O11S
Formula Weight: 750.9
MOL File: 2172820-14-1.mol

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E3 Ligase Ligand-Linker Conjugates 58 Property

storage temp.: -20°C, stored under nitrogen
solubility: DMSO: ≥ 100 mg/mL (133.17 mM)
form: Solid
color: Colorless to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 7105
Product name: VH032amide-PEG5-acid
Purity: ≥95%(HPLC)
Packaging: 25
Price: $199
Updated: 2021/12/16

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E3 Ligase Ligand-Linker Conjugates 58 Chemical Properties,Usage,Production

Biological Activity

(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1].

storage

Store at -20°C

References

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

E3 Ligase Ligand-Linker Conjugates 58 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 Ligase Ligand-Linker Conjugates 58 Suppliers

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2172820-14-1, E3 Ligase Ligand-Linker Conjugates 58Related Search:

E3 Ligase Ligand-Linker Conjugates 58

(S,R,S)-AHPC-PEG5-COOH

VH032-PEG5-COOH

VHL Ligand-Linker Conjugates 16

L-Prolinamide, N-(18-carboxy-1-oxo-4,7,10,13,16-pentaoxaoctadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

VH 032 amide-PEG5-acid

(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosan-1-oic acid

1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid

2172820-14-1

C36H54N4O11S