ChemicalBook > CAS DataBase List > MDR652

MDR652

Product Name: MDR652
CAS No.: 1933528-96-1
Chemical Name: MDR652
Synonyms: MDR652;MDR-652, 10 mM in DMSO;1-((2-(tert-Butyl)-4-(3-chlorophenyl)thiazol-5-yl)methyl)-3-(3-fluoro-4-(hydroxymethyl)phenyl)urea;Urea, N-[[4-(3-chlorophenyl)-2-(1,1-dimethylethyl)-5-thiazolyl]methyl]-N'-[3-fluoro-4-(hydroxymethyl)phenyl]-;Inhibitor,Transient receptor potential channels,neuropathic,MDR-652,analgesic,TRP Channel,TRPV1,activity,pain,hTRPV1,MDR 652,inhibit,ligand,MDR652
CBNumber: CB36127944
Molecular Formula: C22H23ClFN3O2S
Formula Weight: 447.95
MOL File: 1933528-96-1.mol

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MDR652 Property

Boiling point:: 600.1±55.0 °C(Predicted)
Density: 1.330±0.06 g/cm3(Predicted)
pka: 12.25±0.46(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0128723
Product name: MDR-652
Purity: 98.17%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0128723
Product name: MDR-652
Purity: 98.17%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0128723
Product name: MDR-652
Purity: 98.17%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0128723
Product name: MDR-652
Purity: 98.17%
Packaging: 100mg
Price: $1250
Updated: 2021/12/16

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MDR652 Chemical Properties,Usage,Production

Uses

MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The Kis are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC50s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity[1].

in vivo

MDR-652 (0.5 and 5 mg/kg) displays a dose-dependent decrease of body temperature, supporting that MDR-652 displays TRPV1 agonism in the intact animal^[1].
MDR-652 (5-10 mg/kg; i.p. and s.c.) blocks the neuropathic pain completely, indicating 100% maximum possible effect (MPE) ^[1].
MDR-652 has a promising topical pharmacokinetic profile^[1].
MDR-652 has no significant toxicity. In a single-dose toxicity study, the LD₅₀ of MDR-652 is higher than 200 and 2000 mg/kg in i.p. and p.o. administration, respectively^[1].

Animal Model:	ICR mouse^[1]
Dosage:	0.5 and 5 mg/kg
Administration:	Administered intraperitoneally; 7 hours
Result:	Decreased body temperature in a dose-dependent manner.

Animal Model:	Rats with spinal nerve ligation (SNL) model^[1]
Dosage:	1, 2, 5, and 10 mg/kg
Administration:	Administered intraperitoneally and subcutaneously; 24 hours
Result:	The i.p. administration exhibited an excellent and dose dependent analgesic profile with an ED₅₀ of 0.5-2 mg/kg. The subcutaneous injection (sc) also displayed an excellent analgesic outcome with maximum effect at 30 min after administration.

IC 50

hTRPV1: 11.4 nM (Ki); rTRPV1: 23.8 nM (Ki); hTRPV1: 5.05 nM (EC₅₀); rTRPV1: 93 nM (EC₅₀)

References

[1] Jihyae Ann, et al. Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. J Med Chem. 2020 Jan 9;63(1):418-424. DOI:10.1021/acs.jmedchem.9b01046

MDR652 Preparation Products And Raw materials

Raw materials

Preparation Products

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1933528-96-1, MDR652Related Search:

MDR652

Urea, N-[[4-(3-chlorophenyl)-2-(1,1-dimethylethyl)-5-thiazolyl]methyl]-N'-[3-fluoro-4-(hydroxymethyl)phenyl]-

1-((2-(tert-Butyl)-4-(3-chlorophenyl)thiazol-5-yl)methyl)-3-(3-fluoro-4-(hydroxymethyl)phenyl)urea

Inhibitor,Transient receptor potential channels,neuropathic,MDR-652,analgesic,TRP Channel,TRPV1,activity,pain,hTRPV1,MDR 652,inhibit,ligand,MDR652

MDR-652, 10 mM in DMSO

1933528-96-1

C22H23ClFN3O2S