4-OXO-4-(2-THIENYL)BUTYRIC ACID

Product Name: 4-OXO-4-(2-THIENYL)BUTYRIC ACID
CAS No.: 4653-08-1
Chemical Name: 4-OXO-4-(2-THIENYL)BUTYRIC ACID
Synonyms: 4-Oxo-4-(thiophen-2-yl);3-(2-THENOYL)PROPIONIC ACID;3-(2-Theonyl)Propionic acid;γ-Oxo-2-thiophenebutyric acid;γ-Oxo-2-thiophenebutanoic acid;4-OXO-4-THIEN-2-YLBUTANOIC ACID;3-(ALPHA-THENOYL)PROPIONIC ACID;4-OXO-4-(2-THIENYL)BUTYRIC ACID;4-OXO-4-(2-THIENYL)BUTANOIC ACID;2-Thiophenebutanoic acid, γ-oxo-
CBNumber: CB3674958
Molecular Formula: C8H8O3S
Formula Weight: 184.21
MOL File: 4653-08-1.mol

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4-OXO-4-(2-THIENYL)BUTYRIC ACID Property

Melting point:: 118-121 °C(lit.)
Boiling point:: 400.5±25.0 °C(Predicted)
Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.44±0.17(Predicted)
Appearance: White to off-white Solid
BRN: 133870
CAS DataBase Reference: 4653-08-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 574406
Product name: 4-Oxo-4-(2-thienyl)butyric acid
Purity: 97%
Packaging: 5g
Price: $77.1
Updated: 2023/06/20

TRC

Product number: O864005
Product name: 4-Oxo-4-(thien-2-yl)butanoicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK154146
Product name: 4-Oxo-4-(2-thienyl)butyric acid
Purity: 97%
Packaging: 1g
Price: $35
Updated: 2021/12/16

AK Scientific

Product number: Y9163
Product name: 4-Oxo-4-(2-thienyl)butanoicacid
Packaging: 1g
Price: $68
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK154146
Product name: 4-Oxo-4-(2-thienyl)butyric acid
Purity: 97%
Packaging: 5g
Price: $83
Updated: 2021/12/16

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4-OXO-4-(2-THIENYL)BUTYRIC ACID Chemical Properties,Usage,Production

Chemical Properties

Beige crystalline powder

Definition

ChEBI: A 4-oxo monocarboxylic acid that is butyric acid bearing oxo and 2-thienyl groups at position 4.

Synthesis

188290-36-0

108-30-5

4653-08-1

General procedure for the synthesis of 3-(2-thiophenecarbonyl)propionic acid from the compound (CAS:188290-36-0) and succinic anhydride: thiophene (5.0 g, 0.059 mol) and succinic anhydride (7.13 g, 0.0713 mol) were dissolved in ethylene dichloride (50 mL). Aluminum chloride (17.43 g, 0.131 mol) was added at room temperature and the resulting mixture was heated to reflux for 1 hour with stirring. The reaction mixture was cooled to room temperature and diluted with 30 mL of a 1:1 mixture of water and concentrated hydrochloric acid. After stirring for 10 min, the solid was separated by diafiltration and washed with water and dilute hydrochloric acid (50 mL). The solid was dried at room temperature to give 9.8 g (89% yield) of 3-(2-thiophenecarbonyl)propionic acid with a melting point of 103-107°C. 1H NMR (CDCl3, δ): 7.69 (dd, 1H), 7.58 (dd, 1H), 7.07 (dd, 1H), 3.9 (bs, 1H), 3.23 (t, 2H), 2.74 (t, 2H). 2H).

References

[1] Patent: WO2004/26848, 2004, A1. Location in patent: Page 33
[2] European Journal of Pharmacology, 2014, vol. 727, # 1, p. 1 - 7
[3] Patent: CN108341797, 2018, A. Location in patent: Paragraph 0008; 0017
[4] Patent: WO2010/76188, 2010, A1. Location in patent: Page/Page column 17-19
[5] Archiv der Pharmazie, 1988, vol. 321, # 10, p. 735 - 738

4-OXO-4-(2-THIENYL)BUTYRIC ACID Preparation Products And Raw materials

Raw materials

Sodium sulfate Succinic anhydride Thiophene Aluminum chloride Hydrochloric acid Dichloromethane Sodium hydroxide

Preparation Products

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4-OXO-4-(2-THIENYL)BUTYRIC ACID Suppliers

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4653-08-1, 4-OXO-4-(2-THIENYL)BUTYRIC ACIDRelated Search:

CIS-2-(2-THIOPHENECARBONYL)-1-CYCLOHEXANECARBOXYLIC ACID, 99 TRANS-2-(2-THIOPHENECARBONYL)-1-CYCLOHEXANECARBOXYLIC ACID, 99 4-OXO-4-(2-THIENYL)BUTYRIC ACID 4-(2-THIENYL)BUTYRIC ACID 4-THIEN-2-YL-2,4-DIOXOBUTANOIC ACID 4-(5-CHLORO-2-THIENYL)-4-OXOBUTYRIC ACID CHEMBRDG-BB 6539802 4-(5-METHYL-2-THIENYL)-4-OXOBUTYRIC ACID ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE 2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRIC ACID METHYL ESTER 1-(2-OXO-2-THIEN-2-YLETHYL)CYCLOHEXANECARBOXYLIC ACID ETHYL 3-[2-(4-CHLOROPHENYL)HYDRAZONO]-2,4-DIOXO-4-(2-THIENYL)BUTANOATE 4-OXO-4-THIOPHEN-2-YL-BUTYRIC ACID ETHYL ESTER ETHYL 3-[2-(2-CHLOROPHENYL)HYDRAZONO]-2,4-DIOXO-4-(2-THIENYL)BUTANOATE 3-BROMO-4-OXO-4-THIEN-2-YLBUTANOIC ACID ETHYL 2,4-DIOXO-3-(2-PHENYLHYDRAZONO)-4-(2-THIENYL)BUTANOATE ETHYL 2,4-DIOXO-4-(2-THIENYL)-3-(2-[2-(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)BUTANOATE METHYL 4-(5-CHLOROTHIEN-2-YL)-2,4-DIOXOBUTANOATE

3-(2-THENOYL)PROPIONIC ACID

4-OXO-4-THIEN-2-YLBUTANOIC ACID

4-OXO-4-(THIOPHEN-2-YL)BUTANOIC ACID

4-OXO-4-THIOPHEN-2-YL-BUTYRIC ACID

4-OXO-4-(2-THIENYL)BUTANOIC ACID

4-OXO-4-(2-THIENYL)BUTYRIC ACID

3-(ALPHA-THENOYL)PROPIONIC ACID

γ-Oxo-2-thiophenebutanoic acid

4-(2-Thienyl)-4-oxo-butyric acid, GC 97%

4-(2-THIENYL)-4-OXO-BUTYRIC ACID, 97 %

4-OXO-4-(2-THIENYL)BUTYRIC ACID 95%

γ-Oxo-2-thiophenebutyric acid

4-Oxo-4-(2-thienyl)butanoic acid,97%

4-Oxo-4-(thien-2-yl)butyric acid, 3-(2-Thenoyl)propionic acid

4-Oxo-4-(thiophen-2-yl)

3-(2-Theonyl)Propionic acid

JR-6736, 4-Oxo-4-(thiophen-2-yl)butanoic acid, 97%

2-Thiophenebutanoic acid, γ-oxo-

4653-08-1

465-38-1

4653-8-1

Building Blocks

Thiophenes

Heterocyclic Building Blocks

CARBOXYLIC ACID

Heterocyclic Compounds

Building Blocks

Heterocyclic Building Blocks

Thiophenes