3-Amino-4-chlorobenzoic acid

Product Name: 3-Amino-4-chlorobenzoic acid
CAS No.: 2840-28-0
Chemical Name: 3-Amino-4-chlorobenzoic acid
Synonyms: 4,3-CABA;3-Amino-4-chL;3-Amino-4-chloro;TIMTEC-BB SBB003842;Intedanib Impurity 4;4-chloro-3-AMino acid;Sunitinib Impurity 68;5-CARBOXY-2-CHLOROANILINE;3-Amino-4-chlorbenzoesure;3-AMINO-4-CHLOROBENZOIC ACID
CBNumber: CB3680342
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 2840-28-0.mol

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3-Amino-4-chlorobenzoic acid Property

Melting point:: 214-215 °C (lit.)
Boiling point:: 250°C (rough estimate)
Density: 1.3246 (rough estimate)
vapor pressure: 0.001Pa at 25℃
refractive index: 1.5560 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 4.13±0.10(Predicted)
color: Light beige to beige
BRN: 2085846
InChIKey: DMGFVJVLVZOSOE-UHFFFAOYSA-N
LogP: 1.6 at 25℃
Dissociation constant: 2.7-2.9 at 25℃
CAS DataBase Reference: 2840-28-0(CAS DataBase Reference)
NIST Chemistry Reference: 3-Amino-4-chlorobenzoic acid(2840-28-0)
EPA Substance Registry System: Benzoic acid, 3-amino-4-chloro- (2840-28-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
TSCA: Yes
HS Code: 29224995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 07370
Product name: 3-Amino-4-chlorobenzoic acid
Purity: ≥98.0% (T)
Packaging: 25g
Price: $51.4
Updated: 2023/06/20

TCI Chemical

Product number: A0635
Product name: 3-Amino-4-chlorobenzoic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: A0635
Product name: 3-Amino-4-chlorobenzoic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 500g
Price: $197
Updated: 2025/07/31

TRC

Product number: A617745
Product name: 3-Amino-4-chlorobenzoic acid
Packaging: 10g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA00602
Product name: 3-Amino-4-chlorobenzoic acid
Packaging: 500g
Price: $90
Updated: 2021/12/16

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3-Amino-4-chlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

3-Amino-4-chlorobenzoic Acid is a useful reagent for preparation of novel bis-triazolyl-aryl-benzimidazole-thiol derivatives.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

40872-87-5

2840-28-0

General procedure for the synthesis of 3-amino-4-chlorobenzoic acid from methyl 3-amino-4-chlorobenzoate: to a stirred solution of methyl 3-amino-4-chlorobenzoate (0.300 g, 1.62 mmol) in tetrahydrofuran (20 mL) was added a solution of lithium hydroxide (0.340 g, 8.10 mmol) in water (5 mL). The reaction mixture was stirred at room temperature for 12 hours (the reaction progress was monitored by silica gel thin layer chromatography with ethyl acetate-hexane as the unfolding agent, 1:1, v/v). After completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting lithium salt was acidified with 1% (w/v) citric acid solution at 0 °C and extracted with ethyl acetate (2 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3-amino-4-chlorobenzoic acid as a white solid (yield 0.200 g, 72.01%).

Purification Methods

Crystallise the acid from water. [Beilstein 14 IV 1115.]

References

[1] Patent: US2012/184548, 2012, A1. Location in patent: Page/Page column 43

3-Amino-4-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-4-chlorobenzoic acid Suppliers

Americas 1 Belgium 2 China 244 Europe 3 Germany 7 India 39 Japan 5 Slovakia 1 Switzerland 2 Ukraine 2 United Kingdom 12 United States 42 Global 360

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View Lastest Price from 3-Amino-4-chlorobenzoic acid manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 3-amino-4-chlorobenzoic acid 2840-28-0
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-05-12

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Amino-4-chlorobenzoic acid 2840-28-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-24

Career Henan Chemical Co

Product: 3-Amino-4-chlorobenzoic acid 2840-28-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

2840-28-0, 3-Amino-4-chlorobenzoic acidRelated Search:

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TIMTEC-BB SBB003842

4-CHLORO-3-AMINO BENZOIC ACID

5-CARBOXY-2-CHLOROANILINE

3-AMINO-4-CHLOROBENZOIC ACID

2-AMINO-4-CARBOXY-1-CHLOROBENZENE

Benzoic acid, 3-amino-4-chloro-

3-Amino-4-chlorobenzoic acid, 98+%

4,3-CABA

3-AMINO-4-CHLORO BENZOIC ACID 98%

4-CHLORO-3-AMINO BENZOIC ACID 98+%

4-chloro-3-AMino acid

Intedanib Impurity 4

3-Amino-4-chloro

3-Amino-4-chlorobenzoic Acid &gt

3-Amino-4-chL

3-Amino-4-chlorobenzoic acid USP/EP/BP

3-Amino-4-chlorbenzoesure

Sunitinib Impurity 68

2840-28-0

2840-28-4

Specialty Synthesis

Unnatural Amino Acid Derivatives

Peptide Synthesis

Aromatic Amino Acids

Benzoic acid

Organic acids

Aromatic Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives

FINE Chemical & INTERMEDIATES

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