NIALAMIDE
- Product Name
- NIALAMIDE
- CAS No.
- 51-12-7
- Chemical Name
- NIALAMIDE
- Synonyms
- BEIH;Mygal;Espril;Niamid;Niazin;Nyazin;Nyezin;P 1133;Surgex;NF-XIII
- CBNumber
- CB3687497
- Molecular Formula
- C16H18N4O2
- Formula Weight
- 298.34
- MOL File
- 51-12-7.mol
NIALAMIDE Property
- Melting point:
- 152-154 °C(lit.)
- Boiling point:
- 439.76°C (rough estimate)
- Density
- 1.1183 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- −20°C
- solubility
- ethanol: clear to hazy
- pka
- 11.13±0.23(Predicted)
- form
- Solid
- color
- White to off-white
- Merck
- 13,6515
- BRN
- 492941
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-40
- Safety Statements
- 22-26-36
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- NS1225000
- F
- 10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 51-12-7(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): 1000, 1700 orally; 742, 760 i.p. (Delahunt)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 252999
- Product name
- Nialamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $118
- Updated
- 2023/06/20
- Product number
- 460720
- Product name
- Nialamide
- Packaging
- 500mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- N407730
- Product name
- Nialamide
- Packaging
- 5g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- 47844
- Product name
- Nialamide
- Packaging
- 5G
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- INB0001027
- Product name
- NIALAMIDE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $902
- Updated
- 2021/12/16
NIALAMIDE Chemical Properties,Usage,Production
Chemical Properties
White, crystalline powder. Low solubility in water; good solubility in slightly acid solution. It is stable in crystalline form, suspension, and solution.
Originator
Niamid,Pfizer,US,1959
Uses
MAO inhibitor
Uses
Nialamide is a nonselective monoamine oxidase (MAO) inhibitor that is used as an antidepressant.
Definition
ChEBI: 3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide is an organooxygen compound and an organonitrogen compound. It is functionally related to a beta-amino acid.
Manufacturing Process
Methyl acrylate, 28.0 g (0.4 mol) was added dropwise during one hour to a
solution containing 54.8 g (0.4 mol) of isonicotinic acid hydrazide (isoniazid)
and 10 ml of glacial acetic acid in 400 ml of tertiary butyl alcohol. The
resulting solution then was heated for 18 hours on a steam bath.
Concentration of the reaction mixture to 100 ml yielded 13.0 g of unreacted
isonicotinic acid hydrazide. The filtrate was concentrated to a thick syrup
which was triturated with anhydrous ether and recrystallized from isopropyl
alcohol; MP 87°C to 88.5°C. Elemental analysis of the product gave 1-
isonicotinyl-2-(β-carbomethoxyethyl)hydrazine.
A slurry of 7.5 g (0.034 mol) of 1-isonicotinyl-2-(carbomethoxyethyl)-
hydrazine and 5 ml of benzylamine is heated with stirring at 130°C for three
hours. The cooled mass is then recrystallized from ethyl acetate to yield white
needles melting at 151.1°C to 152.1°C.
brand name
Nialamid;Niamidal;Niamide;Niaquital;Niaquitil;Novazid;Nuredal;Psyco-retard;Surgexl.
Therapeutic Function
Antidepressant
World Health Organization (WHO)
Nialamide, a monoamine oxidase inhibitor (MAOI), was introduced in 1959 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus nialamide remains available in several countries.
General Description
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.
Hazard
Toxic in overdose.
Biological Activity
Non-selective MAO-A/B inhibitor.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Mutation data reported. Experimental reproductiveeffects. An antidepressant. When heated to decompositionit emits toxic fumes of NOx.
NIALAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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