ChemicalBook > CAS DataBase List > 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

Product Name: 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID
CAS No.: 668484-45-5
Chemical Name: 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID
Synonyms: 2-(PIPERDIN-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, N1-BOC PROTECTED;2-[1-(tert-butoxycarbonyl)piperid-4-yl]-1,3-thiazole-4-carboxylic acid;2-[1-(TERT-BUTOXYCARBONYL)PIPERDIN-4-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid;1-Piperazinecarboxylic acid, 4-(4-carboxy-2-thiazolyl)-, 1-(1,1-dimethylethyl) ester;1-(tert-Butoxycarbonyl)-4-(4-carboxy-1,3-thiazol-2-yl)piperidine, 2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-carboxy-1,3-thiazole
CBNumber: CB3698558
Molecular Formula: C13H19N3O4S
Formula Weight: 313.37
MOL File: 668484-45-5.mol

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2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Property

Melting point:: 162 °C
Boiling point:: 0°C
Density: 1.332±0.06 g/cm3(Predicted)
Flash point:: 0°C
storage temp.: 2-8°C
pka: 1.35±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0019956
Product name: 2-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)THIAZOLE-4-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 500MG
Price: $845.46
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0019956
Product name: 2-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)THIAZOLE-4-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $911.3
Updated: 2021/12/16

Ambeed

Product number: A750294
Product name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylicacid
Purity: 98%
Packaging: 100mg
Price: $33
Updated: 2021/12/16

Ambeed

Product number: A750294
Product name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylicacid
Purity: 98%
Packaging: 250mg
Price: $61
Updated: 2021/12/16

Ambeed

Product number: A750294
Product name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $171
Updated: 2021/12/16

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2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

867065-53-0

668484-45-5

General procedure for the synthesis of 2-[1-(tert-butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid from ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate: ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid (2.0 g) was dissolved in ethanol (10 mL) and tetrahydrofuran (10 mL) as a mixed solvents and 2 N aqueous sodium hydroxide solution (5 mL) was added. The reaction mixture was stirred at 60 °C for 2 hours. After completion of the reaction, the pH was adjusted to 1 with 1 N hydrochloric acid and a precipitate was precipitated, which was collected by filtration and dried to give a light-colored solid product (1.7 g, 94% yield).

References

[1] Patent: US2018/141923, 2018, A1. Location in patent: Paragraph 0599; 0602; 0603

2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Suppliers

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668484-45-5, 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACIDRelated Search:

TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 4-Formyl-2-isopropylthiazole 4-Thiazolecarboxylicacid,2-(1-methylethyl)-(9CI) tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate 2-PROPYL-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE

2-(PIPERDIN-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, N1-BOC PROTECTED

2-[1-(TERT-BUTOXYCARBONYL)PIPERDIN-4-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

2-[1-(tert-butoxycarbonyl)piperid-4-yl]-1,3-thiazole-4-carboxylic acid

2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid

1-(tert-Butoxycarbonyl)-4-(4-carboxy-1,3-thiazol-2-yl)piperidine, 2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-carboxy-1,3-thiazole

1-Piperazinecarboxylic acid, 4-(4-carboxy-2-thiazolyl)-, 1-(1,1-dimethylethyl) ester

668484-45-5