3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
- Product Name
- 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
- CAS No.
- 145959-21-3
- Chemical Name
- 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
- Synonyms
- 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE;Benzamide, 3-chloro-N-methoxy-N-methyl-
- CBNumber
- CB3705135
- Molecular Formula
- C9H10ClNO2
- Formula Weight
- 199.63
- MOL File
- 145959-21-3.mol
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Property
- Boiling point:
- 335.9±25.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Colourless
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FC149328
- Product name
- 3-Chloro-N-methoxy-N-methylbenzamide
- Packaging
- 250mg
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- FC149328
- Product name
- 3-Chloro-N-methoxy-N-methylbenzamide
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC149328
- Product name
- 3-Chloro-N-methoxy-N-methylbenzamide
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
- Product number
- FC149328
- Product name
- 3-Chloro-N-methoxy-N-methylbenzamide
- Packaging
- 2g
- Price
- $271
- Updated
- 2021/12/16
- Product number
- HCH0021721
- Product name
- 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $289.8
- Updated
- 2021/12/16
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Chemical Properties,Usage,Production
Uses
3-Chloro-N-methoxy-N-methylbenzamide is an intermediate in the synthesis of ketamine related compounds with potential anesthetic properties.
Synthesis
873-63-2
6638-79-5
145959-21-3
General procedure for the synthesis of 3-chloro-N-methoxy-N-methylaniline from 3-chlorobenzyl alcohol and dimethylhydroxylamine hydrochloride: in a pre-oven-dried 15 mL glass vial fitted with a magnetic stir bar, Cu(OAc)2-H2O (12 mg, 6 mol%), N,O-dimethylhydroxylamine hydrochloride (117 mg, 1.2 mmol), 3- chlorobenzyl alcohol (1 mmol), 70% TBHP aqueous solution (0.17 mL, 1.2 mmol), CaCO3 (120 mg, 1.2 mmol), and MeCN (1 mL). Subsequently, the glass vials were rinsed three times with nitrogen and the reaction mixture was stirred at room temperature for 1 hour. Next, the reaction mixture was continued to be stirred at 80 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature. All volatiles were removed under vacuum. The product was extracted with EtOAc (20 mL) and the organic layer was washed with saturated aqueous NaHCO3 solution. Subsequently, the organic layer was dried with Na2SO4 and the solvent was removed under vacuum. Finally, the Weinreb amide product was purified by silica gel column chromatography (100-200 mesh) using a gradient elution of petroleum ether (boiling point 60-80 °C) and EtOAc. All amide products were identified by GC-MS, 1H NMR and 13C NMR spectral analysis.
References
[1] Synthesis (Germany), 2015, vol. 47, # 4, p. 526 - 532
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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