ChemicalBook > CAS DataBase List > 7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE

7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE

Product Name
7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE
CAS No.
842964-18-5
Chemical Name
7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE
Synonyms
5LUB;AKOS B014392;Compound 11 ，E0363;ART-CHEM-BB B014392;TIMTEC-BB SBB007057;δ-Secretase inhibitor 11;delta-Secretase inhibitor, CP11;δ-secretase inhibitor 11, 10 mM in DMSO;Delta-Secretase inhibitor, CP11 - Bio-X ?;7-morpholin-4-yl-2,1,3-benzoxadiazol-4-amine
CBNumber
CB3721759
Molecular Formula
C10H12N4O2
Formula Weight
220.23
MOL File
Mol file
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7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE Property

Boiling point:
455.4±55.0 °C(Predicted)
Density 
1.390±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (567.59 mM; Need ultrasonic)
pka
1.91±0.25(Predicted)
form 
Solid
color 
Brown to dark brown
InChI
InChI=1S/C10H12N4O2/c11-7-1-2-8(10-9(7)12-16-13-10)14-3-5-15-6-4-14/h1-2H,3-6,11H2
InChIKey
LWCSTSZSZFUHAT-UHFFFAOYSA-N
SMILES
N1=C2C(N3CCOCC3)=CC=C(N)C2=NO1
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Safety

WGK Germany 
WGK 3
HazardClass 
IRRITANT
Storage Class
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Dermal
Acute Tox. 4 Oral
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3144
Product name
delta-Secretase inhibitor, CP11
Purity
≥95% (HPLC)
Packaging
10MG
Price
$66.6
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3144
Product name
delta-Secretase inhibitor, CP11
Purity
≥95% (HPLC)
Packaging
50MG
Price
$268
Updated
2025/07/31
Matrix Scientific
Product number
033321
Product name
7-Morpholin-4-yl-benzo[1,2,5]oxadiazol-4-ylamine
Packaging
1g
Price
$485
Updated
2021/12/16
AK Scientific
Product number
0399AF
Product name
7-Morpholin-4-yl-benzo[1,2,5]oxadiazol-4-ylamine
Packaging
1g
Price
$630
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0133060
Product name
7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE
Purity
95.00%
Packaging
500MG
Price
$796.95
Updated
2021/12/16
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7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE Chemical Properties,Usage,Production

Uses

δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research[1].

Biological Activity

Compound 11 (CP11) is an orally active and brain-penetrant delta-secretase (δ-secretase; AEP) inhibitor th at selectively blocks AEP (IC50 = 710 nM) but not other related cysteine proteases (Caspase-3/-8 IC50 = 31.86/86.71 μM, Cathepsin-S/-L IC50 >200 μM) via a dual active site-directed and allosteric mode of inhibition. CP11 inhibits Pala cellular AEP activity in cultures (IC50 = 800 nM) and improves cognitive functions in murine models of Alzheimerμs disease (AD) in vivo (10 mg/kg tau P301S or 5xFAD mice via daily p.o.) by reducing tau and APP cleavage, ameliorating synapse loss and augmenting long-term potentiation.

in vivo

δ-Secretase inhibitor 11 (compound 11) (10 mg/kg, Orally, once daily for 3 months) attenuates neuronal injury induced by OGD (oxygen-glucose deprivation), and specifically exerts neuroprotective actions[1].
δ-Secretase inhibitor 11 (0-10 mg/kg, Orally, once daily for 1.5 and 3 months) inhibits δ-secretase activity, attenuates Aβ deposition and cognitive deficits in 5XFAD mouse model[1].

Animal Model:Tau P301S transgenic mice (n=4 mice per group)[1]
Dosage:10 mg/kg
Administration:Orally, once daily for 3 months
Result:Significantly inhibited the activity of δ-secretase in both wild-type and tau P301S mice brain, increased PP2A activity, and attenuated the truncation and phosphorylation of tau in tau P301S mice. Ameliorated synaptic loss and restored synaptic dysfunction in tau P301S mice.
Animal Model:5XFAD mice[1]
Dosage:2, 5 or 10?mg?kg
Administration:Orally, once daily for 1.5 and 3 months
Result:Attenuated the β-secretase-mediated processing of APP, significantly decreased the concentrations of Aβ 1-40 and Aβ 1-42 in the brain lysates, and attenuated Aβ deposition in a time- and dose-dependent manner.

IC 50

Caspase-3: 31.86 ± 1. μM (IC50); Caspase-8: 86.71 ± 10 μM (IC50)

References

[1] Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740. DOI:10.1038/ncomms14740

7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE Suppliers

China 39 Germany 1 Russia 2 United States 4 Global 46
Zhengzhou Converging Chemical Co. LTD
Tel
0371-53399770 18037166334
Email
3857571523@qq.com
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China
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6180
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4795
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55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
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2495
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
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2968
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
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58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
4023
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58
Changzhou Xuanye Technology Co., Ltd
Tel
15195022192
Email
279776773@qq.com
Country
China
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2000
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58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
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54995
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58

842964-18-5, 7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINERelated Search:


  • AKOS B014392
  • 7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE
  • TIMTEC-BB SBB007057
  • ART-CHEM-BB B014392
  • 7-morpholin-4-yl-2,1,3-benzoxadiazol-4-amine
  • δ-Secretase inhibitor 11
  • 5LUB
  • δ-Secretase inhibitor 11,CNS diseases,Alzheimer's disease,δ secretase inhibitor 11,Caspase,β-amyloid peptide,oxygen-glucose deprivation,amyloid precursor protein,Abeta,asparagine endopeptidase,Inhibitor,APP,AEP,Amyloid-β,Pala cells,δsecretase inhibitor 11,inhibit
  • 2,1,3-Benzoxadiazol-4-amine, 7-(4-morpholinyl)-
  • δ-secretase inhibitor 11, 10 mM in DMSO
  • delta-Secretase inhibitor, CP11
  • 7-morpholinobenzo[c][1,2,5]oxadiazol-4-amine
  • Delta-Secretase inhibitor, CP11 - Bio-X ?
  • Compound 11 ，E0363
  • 842964-18-5