CALPAIN INHIBITOR III

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CALPAIN INHIBITOR III

Product Name: CALPAIN INHIBITOR III
CAS No.: 88191-84-8
Chemical Name: CALPAIN INHIBITOR III
Synonyms: CS-1705;Calp III;MDL 28170;Z-Val-Phe-H;Z-VAL-PHE-CHO;4R)-Tofacitinib;Z-L-Val-L-Phe-OH;Z-VAL-PHE-ALDEHYDE;Cbz-L-Val-L-Phe-OH;CALPAIN INHIBITOR III
CBNumber: CB3723465
Molecular Formula: C22H26N2O4
Formula Weight: 382.45
MOL File: 88191-84-8.mol

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CALPAIN INHIBITOR III Property

Boiling point:: 595.6±50.0 °C(Predicted)
Density: 1.153±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 26 mg/mL
form: White lyophilized solid
pka: 11.05±0.46(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6690
Product name: MDL 28170
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $260
Updated: 2024/03/01

Sigma-Aldrich

Product number: 208722
Product name: Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem
Packaging: 25MG
Price: $216
Updated: 2024/03/01

Alfa Aesar

Product number: J62919
Product name: Calpain Inhibitor III, 95+%
Packaging: 25mg
Price: $139
Updated: 2023/06/20

Cayman Chemical

Product number: 14283
Product name: Calpain Inhibitor III
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14283
Product name: Calpain Inhibitor III
Purity: ≥95%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

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CALPAIN INHIBITOR III Chemical Properties,Usage,Production

Description

MDL-28170 (88191-84-8) is a potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1?It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2?Displays neuroprotective effects in neurotrauma rodent models.3?Calpain I Ki?= 8 nM; Cathepsin B Ki?= 24 nM in isolated enzyme assays. IC50?= 0.3 μM in intact cell assay.4

Uses

MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects.

Uses

Inhibits calpain proteolysis

Definition

ChEBI: A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpai I and II, and is also a gamma-secretase inhibitor.

General Description

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.

Biological Activity

Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo .

Biochem/physiol Actions

Cell permeable: yes

References

1) Chard?et al.?(1995),?Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases; Neuroscience,?65?1099 2) Li?et al.?(1998),?Postischemic treatment with calpain inhibitor MDL28170 ameliorates brain damage in a gerbil model of global ischemia; Neurosci. Lett.,?247?17 3) Thompson?et al. (2010),?A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model; J. Neurotrauma,?27?2233 4) Chatterjee?et al.?(1998),?D-amino acid containing, high-affinity inhibitors of recombinant human calpain I; J. Med. Chem.,?41?2663

CALPAIN INHIBITOR III Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CALPAIN INHIBITOR III manufacturers

Career Henan Chemical Co

Product: CALPAIN INHIBITOR III 88191-84-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

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