(4-BROMOBENZYL)DIMETHYLAMINE

Product Name: (4-BROMOBENZYL)DIMETHYLAMINE
CAS No.: 6274-57-3
Chemical Name: (4-BROMOBENZYL)DIMETHYLAMINE
Synonyms: (4-BROMOBENZYL)DIMETHYLAMINE;4-Bromo-N,N-dimethylbenzylamine;(4-BROMOBENZYL)DIMETHYLBENZYLAMINE;4-(N,N-DIMETHYLAMINOMETHYL)BROMOBENZENE;(4-Bromophenyl)-N,N-dimethylmethylamine;4-Bromo-N,N-dimethyl-Benzenemethanamine;1-(4-broMophenyl)-N,N-diMethylMethanaMine;BenzeneMethanaMine, 4-broMo-N,N-diMethyl-;1-(4-Bromophenyl)-N,N-dimethylmethylamine;[(4-bromophenyl)methyl]dimethylamine - [AC78543]
CBNumber: CB3735194
Molecular Formula: C9H12BrN
Formula Weight: 214.1
MOL File: 6274-57-3.mol

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(4-BROMOBENZYL)DIMETHYLAMINE Property

Melting point:: 165-167 °C
Boiling point:: 121-122 °C(Press: 20 Torr)
Density: 1.320±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: liquid
pka: 8.56±0.28(Predicted)
color: Clear, colourless

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 3632-9-X0
Product name: 4-Bromo-N,N-dimethylbenzylamine
Purity: 98%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB134276
Product name: (4-Bromobenzyl)dimethylamine
Packaging: 250mg
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3632-9-X0
Product name: 4-Bromo-N,N-dimethylbenzylamine
Purity: 98%
Packaging: 5G
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 153013
Product name: (4-Bromobenzyl)dimethylamine
Purity: 95%
Packaging: 1g
Price: $136
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB134276
Product name: (4-Bromobenzyl)dimethylamine
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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(4-BROMOBENZYL)DIMETHYLAMINE Chemical Properties,Usage,Production

Synthesis

124-40-3

589-15-1

6274-57-3

1. In a flask containing 50% aqueous diethylamine (500 mmol) and K2CO3 (50 mmol), a solution of 4-bromobenzyl bromide (50 mmol) in THF (90 mL) was added slowly and dropwise. The reaction mixture was stirred at 60 °C under Ar atmosphere for 24 hours. After completion of the reaction, water (60 mL) was added and extracted with CHCl3 (100 mL x 3). The organic layers were combined, dried with Na2SO4, filtered and concentrated under reduced pressure to give 4-bromobenzyl dimethylamine in 99% yield (boiling point 55 °C/1 mmHg). 2. Mg (40 mmol) was dried with a vacuum pump at 70 °C for 20 min. To the dried Mg was added a solution of 4-bromobenzyldimethylamine (30 mmol) in anhydrous THF (70 mL) and stirred for 1 h at room temperature under Ar atmosphere. Subsequently, anhydrous THF (30 mL) solution of chlorodiphenylphosphine (30 mmol) was slowly added at 0°C and stirred at room temperature for 2 hours. At the end of the reaction, the mixture was filtered and washed with dichloromethane. To the filtrate was added a 30% aqueous solution of H2O2 (60 mmol) at 0 °C and stirred for 1 h at room temperature. After completion of the reaction, the reaction was quenched with water (100 mL) and extracted with chloroform (50 mL x 3). The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. To the residue, diethyl ether (300 mL) was added, stirred for 0.5 h to dissolve the product, filtered and concentrated under reduced pressure to give 4-(diphenylphosphinyl)benzyldimethylamine in 95% yield. 3. To a flask containing anhydrous 1,2-dimethoxyethane (200 mL) solution of 4-(diphenylphosphinoyl)benzyldimethylamine (60 mmol) was added dimethyl sulfate (120 mmol) at 0 °C. The mixture was mixed with a mixture of 2,2-dimethoxyethane (200 mL) and 4-(diphenylphosphinoyl)benzyldimethylamine (60 mmol). The mixture was stirred at 50 °C under Ar atmosphere for 1 hour. Subsequently, LiAlH4 (180 mmol) was added at 0 °C and stirred at room temperature for 2 hours. Upon completion of the reaction, it was quenched with ice, then quenched with 1 M aqueous HBr solution (200 mL) and washed with ether (200 mL x 2). The aqueous phase was extracted with dichloromethane (100 mL x 3), the organic layers were combined, dried with Na2SO4, filtered and concentrated under reduced pressure. To the residue, diethyl ether (300 mL) was added, stirred under Ar atmosphere for 0.5 h. 4-(Diphenylphosphino)benzyltrimethylammonium bromide was obtained by filtration in 79% yield.

References

[1] Tetrahedron, 2010, vol. 66, # 19, p. 3421 - 3426
[2] Tetrahedron, 2013, vol. 69, # 19, p. 3971 - 3977
[3] Chemical Communications, 2012, vol. 48, # 63, p. 7823 - 7825
[4] Journal of Organic Chemistry, 2016, vol. 81, # 18, p. 8520 - 8529
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2667 - 2677

(4-BROMOBENZYL)DIMETHYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-BROMOBENZYL)DIMETHYLAMINE Suppliers

China 49 France 1 India 2 United Kingdom 5 United States 12 Global 69

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6274-57-3, (4-BROMOBENZYL)DIMETHYLAMINERelated Search:

N,N-Dimethylbenzylamine 4-BROMO-N,N-DIETHYLBENZAMIDE 4-(4-BROMOBENZOYL) MORPHOLINE (4-BROMOBENZYL)DIMETHYLAMINE 4-Bromo-N,N-dimethylbenzamide Halofuginone Lactate 1,2-Bis(tetrabromophthalimido) ethane 2-BENZYL-5-BROMOISOINDOLINE-1,3-DIONE 4-BROMO-N,N-DIISOPROPYLBENZYLAMINE, 95 1-(4-bromobenzoyl)-4-methylpiperazine (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE (3-BROMOBENZYL)DIMETHYLAMINE (2-BROMOBENZYL)DIMETHYLAMINE N,N'-(methylenedi-p-phenylene)bis[3,4,5,6,-tetrabromophthalimide] RARECHEM AL FI 0098 5-ACETYL-3-(4-BROMOBENZYL)-1-(4-CHLOROPHENYL)-2,4(1H,3H)-PYRIMIDINEDIONE TIMTEC-BB SBB006035 4,5,6,7-TETRABROMO-2-(OXIRAN-2-YLMETHYL)ISOINDOLINE-1,3-DIONE

(4-BROMOBENZYL)DIMETHYLAMINE

4-(N,N-DIMETHYLAMINOMETHYL)BROMOBENZENE

4-Bromo-N,N-dimethylbenzylamine

(4-BROMOBENZYL)DIMETHYLBENZYLAMINE

(4-Bromophenyl)-N,N-dimethylmethylamine, (4-Bromobenzyl)dimethylamine

1-(4-Bromophenyl)-N,N-dimethylmethylamine

(4-Bromophenyl)-N,N-dimethylmethylamine

BenzeneMethanaMine, 4-broMo-N,N-diMethyl-

1-(4-broMophenyl)-N,N-diMethylMethanaMine

4-Bromo-N,N-dimethyl-Benzenemethanamine

[(4-bromophenyl)methyl]dimethylamine - [AC78543]

6274-57-3

alkyl bromide

Halogenated

Aryl

Organohalides