1-ADAMANTANAMINE SULFATE

Product Name: 1-ADAMANTANAMINE SULFATE
CAS No.: 31377-23-8
Chemical Name: 1-ADAMANTANAMINE SULFATE
Synonyms: antadine;AMANTADINE SULFATE;AMANTADINE SULPHATE;ADAMANTYLAMINE SULFATE;1-ADAMANTAMINE SULFATE;1-AMINOADAMANTANSULFATE;AMANTADINE SULFATE 99+%;1-Adamantylamine sulfate;1-ADAMANTANAMINE SULFATE;1-ADAMANTANAMINE SULPHATE
CBNumber: CB3735518
Molecular Formula: C10H19NO4S
Formula Weight: 249.33
MOL File: 31377-23-8.mol

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1-ADAMANTANAMINE SULFATE Property

Melting point:: 300 °C
storage temp.: Store below +30°C.
solubility: Aqueous Acid (Slightly), Aqueous Base (Slightly)
form: Fine Crystalline Powder
color: White
PH: 4.9 (100g/l, H2O, 20°C) (slurry)
Stability:: Hygroscopic
InChI: InChI=1S/C10H17N.H2O4S/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h7-9H,1-6,11H2;(H2,1,2,3,4)
InChIKey: MYWTWSQFJLXGGQ-JUMAMQMDSA-N
SMILES: NC12CC3CC(CC(C3)C1)C2.S(O)(O)(=O)=O
CAS DataBase Reference: 31377-23-8(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: WGK 3 highly water endangering
HS Code: 2921 30 99

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.18383
Product name: Amantadine sulfate
Purity: for synthesis
Packaging: 100g
Price: $228
Updated: 2025/07/31

TCI Chemical

Product number: A1319
Product name: 1-Adamantanamine Sulfate
Purity: >98.0%(T)
Packaging: 25g
Price: $34
Updated: 2025/07/31

TRC

Product number: A576010
Product name: 1-Adamantanamine Sulfate
Packaging: 500mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA00423
Product name: 1-Aminoadamantane sulphate
Packaging: 250g
Price: $87.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA00423
Product name: 1-Aminoadamantane sulphate
Packaging: 500g
Price: $150
Updated: 2021/12/16

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1-ADAMANTANAMINE SULFATE Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder

Uses

Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

Definition

ChEBI: An alkylammonium sulfate salt obtained by combining amantadine and sulfuric acid in a 2:1 ratio. Used as an antiviral and antiparkinson drug.

in vivo

Amantadine sulfate (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment^[5].

Animal Model:	Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)^[5]
Dosage:	25 mg/kg
Administration:	IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:	Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.

IC 50

CDK2; Bcl-2; Bax

References

[1] Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. DOI:10.1007/s10156-003-0262-6
[2] Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. DOI:10.1212/WNL.0b013e31824e8f0d
[3] Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. DOI:10.1016/s0166-3542(02)00199-7
[4] Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. DOI:10.3390/v13040539
[5] Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. DOI:10.1097/ALN.0000000000000352
[6] Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. DOI:10.3892/ijmm.2015.2289

1-ADAMANTANAMINE SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ADAMANTANAMINE SULFATE Suppliers

Americas 1 Belgium 1 China 105 Czech Republic 1 Europe 2 France 1 Germany 3 India 3 Japan 3 United Kingdom 9 United States 18 Global 147

Sichuan Zhongbang Pharma CO.，LTD

Tel: 0830-0830-2585019 13679670161
Fax: 0830-2589033
Email: sales2@zhongbangst.com
Country: China
ProdList: 105
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
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Energy Chemical

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Fax: 021-58436166
Email: sales8178@energy-chemical.com
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
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LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
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Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
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Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
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Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
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View Lastest Price from 1-ADAMANTANAMINE SULFATE manufacturers

Longyan Tianhua Biological Technology Co., Ltd

Product: 1-ADAMANTANAMINE SULFATE 31377-23-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-11-16

Career Henan Chemical Co

Product: 1-ADAMANTANAMINE SULFATE 31377-23-8
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-21

31377-23-8, 1-ADAMANTANAMINE SULFATERelated Search:

Amantadine N,N-Diethyl-p-phenylenediamine sulfate 1-Adamantylacrylate 1-ADAMANTANAMINE FUMARATE 1,3-Phenylenediamine sulfate 2-(2-Hydroxy)ethyl-p-phenylene diamino sulfate Adamantanamine sulfate 1-AMINO-1-ETHYLCYCLOHEXANE 3-METHYLCYCLOHEXYLAMINE 1-AMINO-1-PROPYLCYCLOHEXANE 1-ADAMANTANAMINE SULFATE Diprobutine (+/-)-2-AMINOHEPTANE SULFATE Cyclooctylamine Iso-amyl-ammonium sulfate

AMANTADINE SULFATE 99+%

1-Adamantylamine sulfate

1-AMINOADAMANTANE SULFATE

1-AMINOADAMANTANE SULPHATE

1-AMINOADAMANTANSULFATE

1-ADAMANTANAMINE SULFATE

1-ADAMANTANAMINE SULPHATE

1-ADAMANTANANAMINE SULPHATE

ADAMANTYLAMINE SULFATE

AMANTADINE SULFATE

AMANTADINE SULPHATE

TRICYCLO[3.3.1.13.7]DECAN-1-AMINE SULFATE (AMANTADINE SULFATE)

amantadine sulphate (INNM)

Adamantan-1-amine sulphate

1-Adamantanamine sulfate,99%

AMANTADINE SULFATE FOR SYNTHESIS

Adamantan-1-amine sulfate

1-ADAMANTAMINE SULFATE

1-Adamantylamine sulphate

1-Adamantanamine Sulfate &gt

antadine

1-ADAMANTANAMINE SULFATE ISO 9001：2015 REACH

Vildagliptin Impurity 16 Hemisulfate

31377-23-8

1377-23-83

1377-23-8

C10H17Nsup1sup2H2SO4

C10H17N12H2SO4

2C10H17NH2SO4

C20H34N2H2SO4

C10H17NH2SO4

2C10H17NH2O4S

C20H36N2O4S

Adamantanes

Adamantane derivatives