ChemicalBook > CAS DataBase List > PHENYLMERCURY NITRATE

PHENYLMERCURY NITRATE

Product Name
PHENYLMERCURY NITRATE
CAS No.
55-68-5
Chemical Name
PHENYLMERCURY NITRATE
Synonyms
phenalco;phenitol;mersolite7;merpectogel;phermernite;phe-mer-nite;PHERMERNITE(R);MERPHENYL NITRATE;phenmerzylnitrate;fenylmerkurinitrat
CBNumber
CB3738746
Molecular Formula
C6H5HgNO3
Formula Weight
339.7
MOL File
55-68-5.mol
More
Less

PHENYLMERCURY NITRATE Property

Melting point:
188-190℃ (decomposition)
solubility 
Very slightly soluble in water and in ethanol (96 per cent), slightly soluble in hot water. It dissolves in glycerol and in fatty oils.
form 
solid
Stability:
Stable.
EPA Substance Registry System
Phenylmercuric nitrate (55-68-5)
More
Less

Safety

RIDADR 
1895
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
55-68-5(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
ING0004640
Product name
PHENYLMERCURIC NITRATE
Purity
95.00%
Packaging
5G
Price
$815.82
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0004640
Product name
PHENYLMERCURIC NITRATE
Purity
95.00%
Packaging
25G
Price
$1174.67
Updated
2021/12/16
AHH
Product number
MT-22399
Product name
phenylmercurynitrate
Purity
98%
Packaging
500g
Price
$560
Updated
2021/12/16
More
Less

PHENYLMERCURY NITRATE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Chemical Properties

Phenylmercuric nitrate PhEur 6.0, and USP32-NF27, is an equimolecular compound of phenylmercuric hydroxide and phenylmercuric nitrate; it occurs as a white, crystalline powder with a slight aromatic odor.

Uses

Pharmaceutic aid (antimicrobial agent).

Production Methods

Phenylmercuric nitrate is readily formed by heating benzene with mercuric acetate, and treating the resulting acetate with an alkali nitrate.

Definition

ChEBI: Phenylmercuric nitrate is a member of benzenes.

brand name

Phenmerzyl Nitrate (Marion Merrell Dow).

General Description

Lustrous scales decomposing at 187-190°C. Very slightly soluble in water. Used as an antiseptic, germicide, fungicide.

Air & Water Reactions

Very slightly soluble in water.

Reactivity Profile

Strongly reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Generally highly toxic. Often react on contact with tissues to give toxic products.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Pharmaceutical Applications

Phenylmercuric salts are used as antimicrobial preservatives mainly in ophthalmic preparations, but are also used in cosmetics, parenteral, and topical pharmaceutical formulations;
Phenylmercuric salts are active over a wide pH range against bacteria and fungi and are usually used in neutral to alkaline solutions, although they have also been used effectively at slightly acid pH. In acidic formulations, phenylmercuric nitrate may be preferred to phenylmercuric acetate or phenylmercuric borate as it does not precipitate.
Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended;
A number of adverse reactions to phenylmercuric salts have been reported, and concern at the toxicity of mercury compounds may preclude the use of phenylmercuric salts under certain circumstances;

Safety Profile

Poison by intravenous route. FDA over-the-counter drug. When heated to decomposition it emits very toxic fumes of Hg and NOx. See also MERCURY COMPOUNDS and NITRATES.

Safety

Phenylmercuric nitrate and other phenylmercuric salts have been widely used as antimicrobial preservatives in parenteral and topical pharmaceutical formulations. However, concern over the use of phenylmercuric salts in pharmaceuticals has increased as a result of greater awareness of the toxicity of mercury and other mercury compounds. This concern must, however, be balanced by the effectiveness of these materials as antimicrobial preservatives and the low concentrations in which they are employed.
Phenylmercuric salts are irritant to the skin at 0.1% w/w concentration in petrolatum.In solution, they may give rise to erythema and blistering 6–12 hours after administration. In a modified repeated insult patch test, a 2% w/v solution was found to produce extreme sensitization of the skin.
Eye drops containing phenylmercuric nitrate as a preservative should not be used continuously for prolonged periods as mercurialentis, a brown pigmentation of the anterior capsule of the lens may occur. Incidence is 6% in patients using eye drops for greater than 6 years; however, the condition is not associated with visual impairment.Cases of atypical band keratopathy have also been attributed to phenylmercuric nitrate preservative in eye drops.
Concern that the absorption of mercury from the vagina may be harmful has led to the recommendation that phenylmercuric nitrate should not be used in intravaginal formulations.
(mouse, IV): 27 mg/kg
(mouse, oral): 50 mg/kg
(rat, SC): 63 mg/kg

storage

All phenylmercuric compound solutions form a black residue of metallic mercury when exposed to light or after prolonged storage. Solutions may be sterilized by autoclaving, although significant amounts of phenylmercuric salts may be lost, hence reducing preservative efficacy, owing to incompatibilities with packaging components or other excipients, e.g. sodium metabisulfite.
Phenylmercuric nitrate should be stored in a well-closed container, protected from light, in a cool, dry place.

Incompatibilities

The antimicrobial activity of phenylmercuric salts may be reduced in the presence of anionic emulsifying agents and suspending agents, tragacanth, starch, talc, sodium metabisulfite,sodium thiosulfate,disodium edetate,and silicates (bentonite, aluminum magnesium silicate, magnesium trisilicate, and kaolin).
Phenylmercuric salts are incompatible with halides, particularly bromides and iodides, as they form less-soluble halogen compounds. At concentrations of 0.002% w/v precipitation may not occur in the presence of chlorides. Phenylmercuric salts are also incompatible with aluminum and other metals, ammonia and ammonium salts, amino acids, and with some sulfur compounds, e.g. in rubber.
Phenylmercuric salts are absorbed by rubber stoppers and some types of plastic packaging components; uptake is usually greatest to natural rubbers and polyethylene, and least to polypropylene. Incompatibilities with some types of filter membranes may also result in loss of phenylmercuric salts following sterilization by filtration.

Regulatory Status

Included in the FDA Inactive Ingredients Database (parenteral and ophthalmic preparations). Included in parenteral products and eye drops in the EU. Included in the Canadian List of Acceptable Nonmedicinal Ingredients (ophthalmic, nasal and otic preparations only up to 0.002%; there must be no other suitable alternative preservative).
Prohibited in first aid antiseptic drug products, antimicrobial diaper rash drug products and vaginal contraceptive drug products in the USA. Limited uses permitted in Japan and the EU for cosmetics.

PHENYLMERCURY NITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

PHENYLMERCURY NITRATE Suppliers

Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
13096311329 028-88469284 616445927
Fax
028-88469284
Email
616445927@qq.com
Country
China
ProdList
2876
Advantage
50
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9947
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
9802
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23931
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28180
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22968
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-61398051 +8613650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
Wuhan Xinyangruihe Chemical Technology Co., Ltd.
Tel
13720274133
Fax
027-83850377
Email
1213219329@qq.com
Country
China
ProdList
3361
Advantage
58

55-68-5, PHENYLMERCURY NITRATERelated Search:


  • Mercury, (nitrato-.kappa.O)phenyl-
  • PHENYLMERCURICNITRATE,CP
  • PHENYLMERCURICNITRATE,NF
  • Nitric acid phenylmercury(II) salt
  • Phenyl Mercuric Nitra
  • MERCURIC PHENYL NITRATE
  • MERPHENYL NITRATE
  • MERCURIC PHENYL NITRATE 98.5%
  • PHERMERNITE(R)
  • PHENYLMERCURY NITRATE
  • PHENYLMERCURIC NITRATE
  • PHENMERZYL NITRATE(R)
  • NITRATOPHENYLMERCURY
  • (nitrato-o)phenyl-mercur
  • fenylmerkurinitrat
  • merpectogel
  • mersolite7
  • nitratophenyl-mercur
  • nitricacid,phenylmercurysalt
  • phe-mer-nite
  • phenalco
  • phenitol
  • phenmerzylnitrate
  • phenylmercury(ii)nitrate
  • phermernite
  • Phenylmercury nitrate(Technical)
  • PHENYLMERCURY NITRATE ISO 9001:2015 REACH
  • 55-68-5
  • C6H5HgNO3