TRIMETHYLSILYL BROMOACETATE Property

Boiling point:

57-58 °C/9 mmHg (lit.)

Density 

1.284 g/mL at 25 °C (lit.)

vapor density 

>1 (vs air)

refractive index 

n20/D 1.442(lit.)

Flash point:

83 °F

storage temp. 

Flammables area

form 

clear liquid

color 

Colorless to Light yellow

Specific Gravity

1.299

Hydrolytic Sensitivity

7: reacts slowly with moisture/water

Sensitive 

Moisture Sensitive

BRN 

1927560

CAS DataBase Reference

18291-80-0(CAS DataBase Reference)

Safety

Hazard Codes 

C

Risk Statements 

10-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

F 

10-19-21

TSCA 

No

HazardClass 

8

PackingGroup 

II

HS Code 

29310099

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

TRIMETHYLSILYL BROMOACETATE Chemical Properties,Usage,Production

Chemical Properties

Clear slightly yellow liquid

Uses

Trimethylsilyl bromoacetate has been used:

• in the preparation of new imidazolium salts functionalized with the trimethylsilyl ester group
• as alkylating agent in the synthesis of succinate fragment of pantocin B (antibiotic natural product)
• in the synthesis of taxol derivatives tethered at C2′ and C-7 to glutamate and folate