2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Product Name
- 2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID
- CAS No.
- 92534-69-5
- Chemical Name
- 2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Synonyms
- AKOS B000133;TIMTEC-BB SBB000165;ART-CHEM-BB B000133;1-METHYL-4-NITRO-5-PYRAZOLECARBOXYLIC ACID;1-methyl-4-nitro-1H-pyrazole-5-carboxylate;2-methyl-4-nitropyrazole-3-carboxylic acid;2-Methyl-4-nitro-2H-pyrazol-3-carboxylic acid;1-METHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID;2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID;1H-Pyrazole-5-carboxylic acid, 1-methyl-4-nitro-
- CBNumber
- CB3742792
- Molecular Formula
- C5H5N3O4
- Formula Weight
- 171.11
- MOL File
- Mol file
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 160-161°C
- Boiling point:
- 399.0±27.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.10±0.50(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M339228
- Product name
- 1-Methyl-4-nitro-1H-pyrazole-5-carboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 011451
- Product name
- 1-Methyl-4-nitro-5-pyrazolecarboxylic acid
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- OR13452
- Product name
- 1-Methyl-4-nitro-1H-pyrazole-5-carboxylicacid
- Packaging
- 5g
- Price
- $392
- Updated
- 2021/12/16
- Product number
- 4H54-1-6P
- Product name
- 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- OR13452
- Product name
- 1-Methyl-4-nitro-1H-pyrazole-5-carboxylicacid
- Packaging
- 1g
- Price
- $143
- Updated
- 2021/12/16
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
16034-46-1
92534-69-5
The general procedure for the synthesis of 1-methyl-4-nitro-pyrazole-5-carboxylic acid from 1-methyl-1H-pyrazole-5-carboxylic acid was as follows: fuming sulfuric acid (1977 mmol) was slowly added dropwise to fuming nitric acid (777 mmol) under strictly controlled temperature conditions. Subsequently, 1-methyl-1H-pyrazole-5-carboxylic acid (277 mmol) was added in batches to ensure that the reaction temperature was maintained below 60 °C. The reaction was carried out at the same temperature. After the addition was completed, the reaction mixture was stirred continuously at the same temperature for 1 hour. Upon completion of the reaction, the mixture was quenched by careful pouring into crushed ice and extracted with ethyl acetate (300 mL x 3). The organic phases were combined, washed sequentially with water (250 mL x 2) and dried with anhydrous sodium sulfate. Finally, the solvent was removed by distillation under reduced pressure to afford 1-methyl-4-nitro-pyrazole-5-carboxylic acid as a light yellow solid in a yield of 23.6 g in 50% yield. [00251] 1H NMR (400 MHz, DMSO-d6) δ: 8.29 (1H, s); 3.95 (3H, s).
References
[1] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, vol. 19, # 12, p. 1326 - 1330
[2] Khimiya Geterotsiklicheskikh Soedinenii, 1983, vol. 19, # 12, p. 1676 - 1679
[3] Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, # 5, p. 976 - 980
[4] Zhurnal Organicheskoi Khimii, 1984, vol. 20, # 5, p. 1073 - 1078
[5] Patent: WO2009/71705, 2009, A1. Location in patent: Page/Page column 39
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 025-58395930
- Fax
- 025-5861-9182
- sales@acornpharma.com
- Country
- China
- ProdList
- 982
- Advantage
- 60
- Tel
- +86-021-54824098 15317552526
- Fax
- 021-54824069
- sales@chemzq.com
- Country
- China
- ProdList
- 254
- Advantage
- 55
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- 18993966060
- Fax
- 0943-8288977
- sales@techbiochem.com
- Country
- China
- ProdList
- 806
- Advantage
- 61
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- +91-22-26355700
- Fax
- +91-22-26355701
- info@clearsynth.com
- Country
- India
- ProdList
- 9679
- Advantage
- 58
View Lastest Price from 2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID manufacturers
- Product
- 2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID 92534-69-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2020-03-05