ChemicalBook > CAS DataBase List > TISSUE PLASMINOGEN ACTIVATOR, HUMAN

TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Product Name
TISSUE PLASMINOGEN ACTIVATOR, HUMAN
CAS No.
189263-81-8
Chemical Name
TISSUE PLASMINOGEN ACTIVATOR, HUMAN
Synonyms
TISSUE PLASMINOGEN ACTIVATOR;TPA;TPA, HUMAN;1-CHAIN TPA;2-CHAIN TPA;TISSUE PLASMINOGEN ACTIVATOR, HUMAN;TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN;TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN;9,10-Bis[N-(m-tolyl)anilino]anthracene;9,10-Bis[N-(m-tolyl)anilino]anthracene
CBNumber
CB3746518
Molecular Formula
C40H32N2
Formula Weight
540.7
MOL File
189263-81-8.mol
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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Property

Melting point:
262 °C
Boiling point:
723.8±53.0 °C(Predicted)
Density 
1.194±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Lyophilized
pka
-0.33±0.50(Predicted)
color 
Light yellow to Yellow to Orange
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
1
HS Code 
2921.59.8090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T0831
Product name
Tissue plasminogen activator human
Packaging
100μG
Price
$512
Updated
2023/06/20
Sigma-Aldrich
Product number
T0831
Product name
Tissue plasminogen activator human
Packaging
1MG
Price
$1150
Updated
2023/06/20
Sigma-Aldrich
Product number
T0831
Product name
Tissue plasminogen activator human
Packaging
100UG
Price
$426
Updated
2022/05/15
TCI Chemical
Product number
B4965
Product name
9,10-Bis[N-(m-tolyl)anilino]anthracene
Purity
>98.0%(HPLC)
Packaging
1g
Price
$268
Updated
2024/03/01
TCI Chemical
Product number
B4965
Product name
9,10-Bis[N-(m-tolyl)anilino]anthracene
Purity
>98.0%(HPLC)
Packaging
200mg
Price
$78
Updated
2024/03/01
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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.

General Description

Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.

Biochem/physiol Actions

tPA is a potent activator of fibrinolysis and converts plasminogen into plasmin and also initiates cell signaling. The plasminogen activation system may also be associated with degradation of amyloid fibrils. It is also known to mediate inflammatory and extracellular matrix remodeling processes and is predicted to participate in disease progression of intracranial aneurysm indicating brain vascular malformations. Upregulation of the gene is observed in aortic aneurysms.

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Suppliers

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189263-81-8, TISSUE PLASMINOGEN ACTIVATOR, HUMANRelated Search:

Tris(acetylacetonato)(1,10-phenanthroline)terbium(III) Bis(8-quinolinolato) zinc 9,10-Bis[N,N-di-(p-tolyl)-amino]anthracene N,N'-Dimethylquinacridone 10-(2-Benzothiazolyl)-2,3,6,7-tetrahydro-1,1,7,7-tetramethyl-1H,5H,11H-(1)benzopyropyrano(6,7-8-I,j)quinolizin-11-one (2,2'-Bipyridine)bis(2-phenylpyridinato)iridium(III) Hexafluorophosphate BIS[2-(2-BENZOXAZOLYL)PHENOLATO]ZINC(II) Quinacridone 9,10-Bis[phenyl(m-tolyl)-amino]anthracene 2-Bromo-9,10-diphenylanthracene Tissue Plasminogen Activator

  • 2-CHAIN TPA
  • 1-CHAIN TPA
  • Tissue Plasminogen Activator from human melanoma cells
  • 9,10-Bis[N-(m-tolyl)anilino]anthracene
  • TISSUE PLASMINOGEN ACTIVATOR, HUMANphenyl)-N,N'-diphenyl-
  • TISSUE PLASMINOGEN ACTIVATOR, HUMAN
  • TISSUE PLASMINOGEN ACTIVATOR
  • TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN
  • TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN
  • TPA, HUMAN
  • TPA
  • 9-N,10-N-bis(3-methylphenyl)-9-N,10-N-diphenylanthracene-9,10-diamine
  • 9,10-Bis[<i>N</i>-(<i>m</i>-tolyl)anilino]anthracene
  • 9,10-Anthracenediamine, N9,N10-bis(3-methylphenyl)-N9,N10-diphenyl-
  • N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-9,10-anthracenediamine
  • N,N'-Diphenyl-N,N'-di(m-tolyl)-9,10-anthracenediamine
  • N9,N10-Diphenyl-N9,N10-di-m-tolylanthracene-9,10-diamine
  • 189263-81-8
  • Serum Related EnzymesEnzymes, Inhibitors, and Substrates
  • Therapeutic EnzymesProteolytic Enzymes and Substrates
  • Tissue Plasminogen Activator
  • Application Index
  • Proteases&Protein Sequencing
  • ProteasesApplication Index
  • Selective Proteolytic Enzymes
  • Serum Proteins and Related Enzymes