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BISPHENOL A DIGLYCIDYL ETHER RESIN

Product Name
BISPHENOL A DIGLYCIDYL ETHER RESIN
CAS No.
1675-54-3
Chemical Name
BISPHENOL A DIGLYCIDYL ETHER RESIN
Synonyms
DGEBA;der332;dgebpa;Epon 828;EPON(R) RESIN 828;E-44;bpdge;EP 274;gy6010;epoxidea
CBNumber
CB3749115
Molecular Formula
C21H24O4
Formula Weight
340.41
MOL File
1675-54-3.mol
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BISPHENOL A DIGLYCIDYL ETHER RESIN Property

Melting point:
40-44 °C
Boiling point:
210 °C / 1mmHg
Density 
1,17 g/cm3
vapor pressure 
0Pa at 25℃
refractive index 
1.5735
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
form 
viscous liquid
color 
White
Water Solubility 
Soluble in 100% ethanol, dimethyl sulfoxide (100 mM), dimethyl formamide, chloroform, methanol, and ethanol (50 mM). Insoluble in water.
BRN 
299026
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP
3.242 at 25℃
CAS DataBase Reference
1675-54-3(CAS DataBase Reference)
IARC
3 (Vol. 47, 71) 1999
EPA Substance Registry System
Bisphenol A diglycidyl ether (1675-54-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38-43
Safety Statements 
28-37/39
WGK Germany 
1
RTECS 
TX3800000
TSCA 
Yes
HS Code 
2910900090
Hazardous Substances Data
1675-54-3(Hazardous Substances Data)
Toxicity
LD50 oral in rabbit: 1980mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
31185
Product name
D.E.R.? 332
Purity
used as embedding medium
Packaging
1kg
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
15138
Product name
Bisphenol A diglycidyl ether
Purity
analyticalstandard
Packaging
500mg
Price
$151
Updated
2024/03/01
TCI Chemical
Product number
B1796
Product name
2,2-Bis(4-glycidyloxyphenyl)propane
Purity
>85.0%(GC)
Packaging
25g
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
B1796
Product name
2,2-Bis(4-glycidyloxyphenyl)propane
Purity
>85.0%(GC)
Packaging
500g
Price
$80
Updated
2024/03/01
Alfa Aesar
Product number
L14817
Product name
Bisphenol A diglycidyl ether
Packaging
25g
Price
$22.4
Updated
2021/12/16
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BISPHENOL A DIGLYCIDYL ETHER RESIN Chemical Properties,Usage,Production

Description

Most epoxy resins result from polymerization of bisphenol A diglycidyl ether (BADGE). Delayed hypersensitivity is caused by the low-molecular-weight monomer BADGE (MW 340 g/mol), the dimer having a much lower sensitization power. This allergen caused contact dermatitis in six workers in a plant producing printed circuits boards made of copper sheets and fiberglass fabric impregnated with a brominated epoxy resin. It can also be contained in adhesives.

Description

PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis. Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-Δ12,14-prostaglandin J2 , and NSAIDS. BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARγ. BADGE binds to PPARγ with an apparent Kd of 100 μM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.

Chemical Properties

Diglycidyl ether of bisphenol A is a colorless to light amber liquid. Slight epoxy odor.

Uses

Bisphenol A derivative. A PPARγ antagonist; exhibits estrogenic activity; An inhibitor of PPARγ and suppressor of TNFα.

Uses

In the manufacture of epoxy resins and polycarbonates for food packaging.

Uses

The uniqueness of D.E.R. 332 epoxy resin is reflected in its maximum epoxide equivalent weight of 178. Because of its high purity and lack of polymer factions, samples embedded using D.E.R. 322 have uniform performance, exceptionally low viscosity and color; and improved elevated temperature properties.

Production Methods

The synthesis of the basic epoxy resin molecule involves the reaction of epichlorohydrin with bisphenol A, the latter requiring two basic intermediates for synthesis, acetone and phenol. Theoretically, the production of the bisphenol A diglycidyl ether requires 2 mol of epichlorohydrin for each mole of the phenol. Epoxy resins of higher molecular weight are obtained by reducing the epichlorohydrin/bisphenol A ratio. This reaction involves consumption of the initial epoxy groups in the epichlorohydrin and of some of the groups formed by dehydrohalogenation.

Definition

ChEBI: Bisphenol A diglycidyl ether is a diarylmethane.

General Description

Odorless yellowish brown liquid. Sinks in water.

Air & Water Reactions

Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. Insoluble in water.

Reactivity Profile

Epoxides, such as BISPHENOL A DIGLYCIDYL ETHER RESIN, are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

Health Hazard

Contact with liquid irritates eyes. Prolonged or repeated contact with skin causes irritation and dermatitis.

Fire Hazard

BISPHENOL A DIGLYCIDYL ETHER RESIN is probably combustible.

Biological Activity

PPAR γ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPAR δ and PPAR α . Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPAR γ . Acts as a PPAR γ agonist in an ECV304 cell line. Also produces PPARg-independent apoptosis of tumor cells via several mechanisms. Active in vivo .

Contact allergens

Most epoxy resins result from polymerization of bisphenol A diglycidyl ether (BADGE). Delayed hypersensitivity is caused by the low-molecular-weight monomer BADGE (Molecular Weight 340 g/mol), the dimer having much a lower sensitization power. This allergen caused contact dermatitis in six workers in a plant producing printed circuits boards made of copper sheets and fiber glass fabric impregnated with a brominated epoxy resin. It can be contained in adhesives.

Biochem/physiol Actions

PPARγ inhibitor that blocks rosiglitazone- and insulin-induced adipogenesis.

Potential Exposure

Diglycidyl ether of bisphenol A is used as a basic active ingredient of epoxy resins.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

Carcinogenicity

In summary, a number of carcinogenicity studies involving the topical application of pure BADGE as well as EPON Resin 828 and other commercial BADGE-based resins have been carried out in experimental animals.Viewing the studies as a whole, the weight of evidence does not show that BADGE or BADGE-based epoxy resins are carcinogenic.

storage

Color Code—Blue: Health Hazard (skin sensitization): Store in a secure location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a dark, cool,well-ventilated area away from strong oxidizers, acids, and heat. Recommended storage (and pumping)temperature=45-50℃.

Shipping

This material is not covered in DOT’sPerformance-Oriented Packaging Standards. It may,however, be classified as a Combustible Liquid, n.o.s. Thisclass requires no shipping label. It falls in Hazard Class 3[each reference to a Class 3 material is modified to read“COMBUSTIBLE LIQUID” when that material is reclassified in accordance with y173.150 (e) or (f) of this subchapter or has a flash point above 60.5℃/141°F but below93℃/200°F], and Packing Group III. The symbol “D” identifies proper shipping names which are appropriate fordescribing materials for domestic transportation but may beinappropriate for international transportation under the provisions of international regulations (e.g., IMO, ICAO). Analternate proper shipping name may be selected when eitherdomestic or international transportation is involved.

Incompatibilities

Easily oxidized in air; presumed to form unstable and explosive peroxides in storage. Incompatible with strong acids; strong oxidizers.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

References

1) Cuzzocrea?et al. (2004),?Rosiglitazone , a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation; Eur. J. Pharmacol.,?483?79 2) Fehlberg?et al. (2003),?Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO; Br. J. Pharmacol.,?139?495 3) Chamorro-Garcia?et al.?(2012),?Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism; Environ. Health Perspect.,?120?984 4) Duque?et al. (2013),?Pharmacological inhibition of PPARgamma increases osteoblastogenesis and bone mass in male C57BL/6 mice; J. Bone Miner. Res.,?28?639

BISPHENOL A DIGLYCIDYL ETHER RESIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BISPHENOL A DIGLYCIDYL ETHER RESIN Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
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View Lastest Price from BISPHENOL A DIGLYCIDYL ETHER RESIN manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
BISPHENOL A DIGLYCIDYL ETHER RESIN 1675-54-3
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
10 tons
Release date
2024-06-17
Hebei Zhanyao Biotechnology Co. Ltd
Product
Bisphenol A Diglycidyl Ether 1675-54-3
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-18
Career Henan Chemical Co
Product
BISPHENOL A DIGLYCIDYL ETHER RESIN 1675-54-3
Price
US $1.00/g
Min. Order
100g
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-23

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