PROTOVERATRINE A Property

Melting point:

267-269°C

alpha 

D25 -40.5° (pyridine); D25 -10.5° (chloroform)

Boiling point:

747.91°C (rough estimate)

Density 

1.36±0.1 g/cm3 (20 ºC 760 Torr)

refractive index 

1.6220 (estimate)

storage temp. 

2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

10.74±0.70(Predicted)

color 

White

Safety

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

22-36/37/39-45

RIDADR 

UN 1544 6.1/PG 1

WGK Germany 

3

RTECS 

FL5750100

HazardClass 

6.1(a)

PackingGroup 

I

Toxicity

LD50 s.c. in male mice: 0.29 mg/kg (Tanaka)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

PROTOVERATRINE A Chemical Properties,Usage,Production

Description

A further alkaloid isolated from Veratrum album, this base yields colourless crystals from EtOH. It is laevorotatory with [α]²⁷_D - 44.1° (pyridine) or - 12.1° (CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour. The complex with maleic acid has been prepared as colourless crystals, m.p. 241.5°C; [α]²⁰_D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one mole of (+)-2-hydroxy-2-methylbutyric acid.

Uses

Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke.

Definition

ChEBI: Protoveratrine A is an alkaloid.

brand name

Protalba (Marion Merrell Dow).

target

Calcium Channel | Potassium Channel

References

Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953)