2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID
- Product Name
- 2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID
- CAS No.
- 206052-01-9
- Chemical Name
- 2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID
- Synonyms
- CUNYTKVXYZYERK-UHFFFAOYSA-N;2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID;Benzenehexanoic acid, 2-(2-propyn-1-yloxy)-
- CBNumber
- CB3756041
- Molecular Formula
- C15H18O3
- Formula Weight
- 246.3
- MOL File
- 206052-01-9.mol
2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID Property
- Boiling point:
- 414.6±35.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ≤100mg/ml in ethanol;50mg/ml in DMSO;100mg/ml in dimethyl formamide
- form
- solid
- pka
- 4.77±0.10(Predicted)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- P9114
- Product name
- 6-(2-Propargyloxyphenyl)hexanoic acid
- Purity
- ≥98%, solid
- Packaging
- 1mg
- Price
- $64.6
- Updated
- 2024/03/01
- Product number
- 75760
- Product name
- PPOH
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $19
- Updated
- 2024/03/01
- Product number
- 75760
- Product name
- PPOH
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 75760
- Product name
- PPOH
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 75760
- Product name
- PPOH
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $595
- Updated
- 2024/03/01
2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID Chemical Properties,Usage,Production
Uses
PPOH is an inhibitor of CYP epoxidase activity on arachadonic acid.
Biological Activity
ppoh is an inhibitor of cyp epoxidase activity on arachadonic acid.arachidonic acid can be converted by microsomal cyp450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds through what is reported as the epoxidase pathway.
in vitro
a previous study found that the inhibition of the epoxygenase pathway with ppoh was able to enhance the microvascular response to increasing renal perfusion pressure. in the presence of 50 mm ppoh, afferent arteriolar diameter decreased by 29% when pressure was increased from 80-160 mmhg. in contrast, the selective cyt-p450 hydroxylase inhibitor, n-methylsulphonyl-12,12-dibromododec-11-enamide could attenuate the vascular response to increasing renal perfusion pressure [1]. in another study, it was shown that among the acetylenic compounds, both ppoh and n-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide were potent and selective inhibitors of microsomal epoxidation with ic50 values of 9 and 13 microm, respectively. inhibition of microsomal activity by ppoh, but not ddms, was time- and nadph-dependent, which was a characteristic of a mechanism-based irreversible inhibitor [2].
IC 50
9 μm for the formation of arachidonate 11,12 epoxides by cyp4a2 and cyp4a3 enzymes, respectively
References
[1] imig, j. d.,falck, j.r., and inscho, e.w. contribution of cytochrome p450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. british journal of pharmacology 127, 1399-1405 (1999).
[2] wang, m. h.,brand-schieber, e.,zand, b.a., et al. cytochrome p450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. journal of pharmacology and experimental therapeutics 284(3), 966-973 (1998).
2-(2-PROPYNYLOXY)-BENZENEHEXANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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