ChemicalBook > CAS DataBase List > Z-LEHD-FMK

Z-LEHD-FMK

Product Name
Z-LEHD-FMK
CAS No.
210345-04-3
Chemical Name
Z-LEHD-FMK
Synonyms
CS-1506;abs813893;Z-LEHD-FMK;CASPASE-9 INHIBITOR;Z-LE(OME)HD(OME)-FMK;CASPASE-9 INHIBITOR I;Z-LEHD-FLUOROMETHYLKETONE;Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK;Z-LEHD-FMK, caspase-9 inhibitor;Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE
CBNumber
CB3758272
Molecular Formula
C32H43FN6O10
Formula Weight
690.73
MOL File
Mol file
More
Less

Z-LEHD-FMK Property

Boiling point:
1008.2±65.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO.
form 
powder
pka
11.11±0.46(Predicted)
color 
White to yellow
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J64966
Product name
Z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethyl ketone trifluoroacetate salt hydrate
Packaging
1mg
Price
$242
Updated
2023/06/20
ApexBio Technology
Product number
B3233
Product name
Z-LEHD-FMK
Packaging
100ul(2mM)
Price
$125
Updated
2021/12/16
ApexBio Technology
Product number
B3233
Product name
Z-LEHD-FMK
Packaging
20ul(10mM)
Price
$125
Updated
2021/12/16
ApexBio Technology
Product number
B3233
Product name
Z-LEHD-FMK
Packaging
1mg
Price
$259
Updated
2021/12/16
ApexBio Technology
Product number
B3233
Product name
Z-LEHD-FMK
Packaging
5mg
Price
$715
Updated
2021/12/16
More
Less

Z-LEHD-FMK Chemical Properties,Usage,Production

Uses

A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition

Biological Activity

Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo .

References

[1]. ozoren n, kim k, burns tf, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer res, 2000, 60(22): 6259-6265.
[2]. mouw g, zechel jl, zhou y, et al. caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. metab brain dis, 2002, 17(3): 143-151.
[3]. colak a, karaoğlan a, barut s, et al. neuroprotection and functional recovery after application of the caspase-9 inhibitor z-lehd-fmk in a rat model of traumatic spinal cord injury. j neurosurg spine, 2005, 2(3): 327-334.

Z-LEHD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Z-LEHD-FMK Suppliers

China 55 Japan 2 Switzerland 2 United Kingdom 4 United States 18 Global 81
Shanghai Zhengyi Pharmaceutical Co., Ltd
Tel
17740884366
Email
derek1229@163.com
Country
China
ProdList
61
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Nanjing Xinmeihe Pharmaceutical Co., Ltd.
Tel
025-57672321 13739186949
Fax
025-57672123
Email
2548785915@qq.com
Country
China
ProdList
294
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19689
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
8084
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
SINO High Goal Chemical Technology Co., Ltd.
Tel
021-57646680 18306277365
Email
guoxin@chembiobanksh.com
Country
China
ProdList
2561
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
7890
Advantage
58
amyjetsci
Tel
027-59626688 18771149750
Email
sales@amyjet.com
Country
China
ProdList
3002
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
6889
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2613
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4988
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29979
Advantage
58
Changsha Fuzhen Biotechnology Co.，LTD
Tel
18670069958 18670069958
Email
3062105966@qq.com
Country
China
ProdList
3262
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Shanghai Silk Dragon Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
3988
Advantage
58
Changzhou Beiyuanxin Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
4375
Advantage
58
Beijing Luyuan Bird Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15810802415@139.com
Country
CHINA
ProdList
6750
Advantage
58
Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
470003480@QQ.COM
Country
CHINA
ProdList
6955
Advantage
58
Hangzhou Lianke Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6349
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Beijing Dakco is Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
bj_info@dakewe.net
Country
CHINA
ProdList
6348
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6600
Advantage
58
Shanghai Minmin Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1914109725@qq.com
Country
CHINA
ProdList
6518
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Beijing Lebo Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6057
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6151
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Shanghai Yaoyun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
912529879@qq.com
Country
CHINA
ProdList
6835
Advantage
58
Beijing Shengke Boyuan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
978560024@qq.com
Country
CHINA
ProdList
6005
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58
Shanghai Boyi Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15800446246@163.com
Country
CHINA
ProdList
5416
Advantage
58
Shenzhen Branch Science and Technology Co., Ltd.
Tel
--
Fax
--
Email
zikerbio@163.com
Country
CHINA
ProdList
6478
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
tech@chinabiovision.com
Country
CHINA
ProdList
2731
Advantage
58
Shanghai Yijie Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
SHYIJIEBIO@126.COM
Country
CHINA
ProdList
3510
Advantage
58
Beijing Chief-East Tech Co.,Ltd (Qwbio)
Tel
--
Fax
--
Email
info@qwbio.com
Country
China
ProdList
6912
Advantage
50
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6748
Advantage
58

210345-04-3, Z-LEHD-FMKRelated Search:


  • BENZYLOXYCARBONYL-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
  • CASPASE-9 INHIBITOR
  • CASPASE-9 INHIBITOR (FLUOROMETHYLKETONE)
  • CASPASE-9 INHIBITOR I
  • Z-LEHD-FLUOROMETHYLKETONE
  • Z-LEHD-FMK
  • Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE
  • Z-LE(OME)HD(OME)-FMK
  • Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
  • Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
  • Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK
  • Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate
  • Z-LE(OME)HD(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
  • CS-1506
  • L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
  • abs813893
  • Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
  • Z-LEHD-FMK，Z-Leu-Glu(OMe)-His-Asp(OMe)-CH?F
  • Z-LEHD-FMK, caspase-9 inhibitor
  • 210345-04-3
  • C32H42FN6O10
  • C32H43FN6O10
  • Caspases/Apoptosis
  • Caspase/Related Products