ChemicalBook > CAS DataBase List > Z-LEHD-FMK

Z-LEHD-FMK

Product Name
Z-LEHD-FMK
CAS No.
210345-04-3
Chemical Name
Z-LEHD-FMK
Synonyms
CS-1506;abs813893;Z-LEHD-FMK;CASPASE-9 INHIBITOR;Z-LE(OME)HD(OME)-FMK;CASPASE-9 INHIBITOR I;Z-LEHD-FLUOROMETHYLKETONE;Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK;Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE;Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
CBNumber
CB3758272
Molecular Formula
C32H43FN6O10
Formula Weight
690.73
MOL File
Mol file
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Z-LEHD-FMK Property

Boiling point:
1008.2±65.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO.
form 
powder
pka
11.11±0.46(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64966
Product name
Z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethyl ketone trifluoroacetate salt hydrate
Packaging
1mg
Price
$242
Updated
2023/06/20
ApexBio Technology
Product number
B3233
Product name
Z-LEHD-FMK
Packaging
1mg
Price
$259
Updated
2021/12/16
ApexBio Technology
Product number
B3233
Product name
Z-LEHD-FMK
Packaging
5mg
Price
$715
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000771
Product name
Z-LEHD-FMK
Purity
95.00%
Packaging
1MG
Price
$811.34
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573379
Product name
Z-LEHD-FMK
Purity
>98%
Packaging
100mg
Price
$2245.7
Updated
2021/12/16
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Z-LEHD-FMK Chemical Properties,Usage,Production

Uses

A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition

Biological Activity

Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo .

References

[1]. ozoren n, kim k, burns tf, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer res, 2000, 60(22): 6259-6265.
[2]. mouw g, zechel jl, zhou y, et al. caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. metab brain dis, 2002, 17(3): 143-151.
[3]. colak a, karaoğlan a, barut s, et al. neuroprotection and functional recovery after application of the caspase-9 inhibitor z-lehd-fmk in a rat model of traumatic spinal cord injury. j neurosurg spine, 2005, 2(3): 327-334.

Z-LEHD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-LEHD-FMK Suppliers

China 53 Japan 2 Switzerland 2 United Kingdom 4 United States 16 Global 77
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210345-04-3, Z-LEHD-FMKRelated Search:


  • BENZYLOXYCARBONYL-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
  • CASPASE-9 INHIBITOR
  • CASPASE-9 INHIBITOR (FLUOROMETHYLKETONE)
  • CASPASE-9 INHIBITOR I
  • Z-LEHD-FLUOROMETHYLKETONE
  • Z-LEHD-FMK
  • Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE
  • Z-LE(OME)HD(OME)-FMK
  • Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
  • Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
  • Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK
  • Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate
  • Z-LE(OME)HD(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
  • CS-1506
  • L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
  • abs813893
  • Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
  • Z-LEHD-FMK，Z-Leu-Glu(OMe)-His-Asp(OMe)-CH?F
  • 210345-04-3
  • C32H42FN6O10
  • C32H43FN6O10
  • Caspases/Apoptosis
  • Caspase/Related Products