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DELTORPHIN II

Product Name
DELTORPHIN II
CAS No.
122752-16-3
Chemical Name
DELTORPHIN II
Synonyms
DADELT II;Declostatin;DELTORPHIN B;Deltorphin 2;DELTORPHIN II;Deltorphin 2(TFA);ala(2)-deltorphini;DELTORPHIN 2?, >98%;Y-{d-Ala}-FEVVG-NH2;[D-ALA2]-DELTORPHIN II
CBNumber
CB3759219
Molecular Formula
C38H54N8O10
Formula Weight
782.88
MOL File
122752-16-3.mol
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DELTORPHIN II Property

Boiling point:
1256.2±65.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble to 1 mg/ml in 10% acetonitrile
form 
solid
pka
4.43±0.10(Predicted)
color 
White
Water Solubility 
Soluble to 1 mg/ml in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T0675
Product name
[D-Ala2]-Deltorphin II
Purity
≥97% (HPLC)
Packaging
1mg
Price
$137
Updated
2024/03/01
Tocris
Product number
1180
Product name
[D-Ala2]-Deltorphin II
Packaging
1
Price
$101
Updated
2021/12/16
Usbiological
Product number
D2735-01B
Product name
Deltorphin II
Packaging
1mg
Price
$531
Updated
2021/12/16
TRC
Product number
D228838
Product name
[D-Ala2]-Deltorphin II
Packaging
10mg
Price
$505
Updated
2021/12/16
ApexBio Technology
Product number
B5072
Product name
[D-Ala2]-Deltorphin II
Packaging
10mg
Price
$520
Updated
2021/12/16
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DELTORPHIN II Chemical Properties,Usage,Production

Uses

[D-Ala2]-Deltorphin II (cas# 122752-16-3) is a useful research chemical.Deltorphin II is one of the naturally occurring peptides with high affinity and selectivity for δ-??opioid binding sites. Deltorphin II showed even higher affinity for δ-??opioid receptors than previously characterized deltorphins. Also, Deltorphin II were identified as new transport substrates of OATP-??A

Definition

ChEBI: Deltorphin B is a peptide.

Biological Activity

[d-ala2]-deltorphin ii (dadelt ii) is a natural agonist of δ opioid receptor with ki or ic50 value of 0.41 nm [1, 2].opioid receptors are most abundant in the central nervous system, but are also localized in many peripheral tissues in mammalian organisms. there are three types of opioid receptors that are well-defined; the μ, δ and κ receptors [2].[d-pen2, d-pen5]enkephalin (dpdpe) is a second highly selective agonist of δ [3]. treatment with dpdpe at 1 m for as short as 3 min significantly diminished the inhibition of the opioid receptor in ng108-15 cells to cyclic amp production. that means neuronal delta opioid receptor underwent acute desensitization. this desensitization was temporally parallel to the phosphorylation of delta opioid receptor 3 min. after agonist stimulation [4].i.c.v. administration of dadelt ii from 0.38-12.78 nm resulted in a dose- and time-related antinociception. 10 min after the administration of dadelt ii, the maximal antinociceptive response was seen. until 60 min after the administration of dadelt ii, effects were detected. these antinociceptive effects of i.c.v. dadelt ii were antagonized by the selective δ antagonist, ici 174,864 [3]. after supraspinal and spinal administration in rats intracerebroventricularly, dadelt ii at 0.2, 1, 10 μg/rat in a dose-related fashion inhibited diarrhea and colonic bead expulsion but did not show any effect on the rate of small intestine transit. spinal administration of dadelt ii at the same dose produced similar results. naltrindole is a selective antagonist of the δ opioid receptor. subcutaneous pretreatment with naltrindole at 1 and 10 mg/kg antagonized effects of dadelt ii partially and completely, respectively [1].

Biochem/physiol Actions

Selective δ2 opioid receptor agonist

storage

Store at -20°C

References

[1]. broccardo m, improta g. antidiarrheal and colonic antipropulsive effects of spinal and supraspinal administration of the natural δ opioid receptor agonist,[d-ala2] deltorphin ii, in the rat. european journal of pharmacology, 1992, 218(1): 69-73.
[2]. janecka a, fichna j, janecki t. opioid receptors and their ligands. current topics in medicinal chemistry, 2004, 4(1): 1-17.
[3]. jiang q, mosberg hi, porreca f. antinociceptive effects of [d-ala2] deltorphin ii, a highly selective δ agonist in vivo. life sciences, 1990, 47(11): pl43-pl47.
[4]. cai y, zhang y, wu y, et al. δ opioid receptor in neuronal cells undergoes acute and homologous desensitization. biochemical and biophysical research communications, 1996, 219(2): 342-347.

DELTORPHIN II Preparation Products And Raw materials

Raw materials

Preparation Products

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DELTORPHIN II Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
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View Lastest Price from DELTORPHIN II manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
DELTORPHIN II 122752-16-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-10
Wuhan Senwayer Century Chemical Co.,Ltd
Product
DELTORPHIN II 122752-16-3
Price
US $0.00/GRAM
Min. Order
1GRAM
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-04

122752-16-3, DELTORPHIN IIRelated Search:


  • M.W. 782.89 C38H54N8O10
  • [D-Ala2,Glu4]deltorphin C
  • [D-Ala2,Glu4]Deltorphin II
  • DADELT II
  • H-TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2
  • DELTORPHIN B
  • DELTORPHIN II
  • [D-ALA2]-DELTORPHIN II
  • TYR-D-ALA-PHE-GLU-VAL-VAL-GLY AMIDE
  • TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2
  • ala(2)-deltorphini
  • deltorphin II, Ala(2)-
  • Deltorphin 2
  • Deltorphin 2(TFA)
  • Deltorphin 2,[D-Ala2]-Deltorphin II, >98%
  • DELTORPHIN 2?, >98%
  • Glycinamide, L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-glutamyl-L-valyl-L-valyl-
  • D-Ala2]-Deltorphin II >=97% (HPLC)
  • Declostatin
  • Y-{d-Ala}-FEVVG-NH2
  • Glycinamide, L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-glutamyl-L-valyl-L-valyl-
  • Deltorphin 2(TFA)|||[D-Ala2]-Deltorphin II
  • Deltorphin II TFA Salt
  • 122752-16-3
  • C38H54N8O10
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • Peptides
  • Opioid Peptides
  • Other Opioid Peptides
  • Opioid receptor and opioid-like receptor