6-FLUORO-DL-TRYPTOPHAN
- Product Name
- 6-FLUORO-DL-TRYPTOPHAN
- CAS No.
- 7730-20-3
- Chemical Name
- 6-FLUORO-DL-TRYPTOPHAN
- Synonyms
- H-Trp(6-F)-OH;H-DL-Trp(6-F)-OH;6-FLUOROTRYPTOPHAN;H-6-FLUORO-DL-TRP-OH;DL-6-FLUOROTRYPTOPHAN;6-fluoro-dl-tryptopha;Tryptophan, 6-fluoro-;6-FLUORO-DL-TRYPTOPHAN;6-Fluoro-DL-tryptophan,97%;6-FLUORO-DL-TRYPTOPHAN USP/EP/BP
- CBNumber
- CB3764974
- Molecular Formula
- C11H11FN2O2
- Formula Weight
- 222.22
- MOL File
- 7730-20-3.mol
6-FLUORO-DL-TRYPTOPHAN Property
- Melting point:
- 280-285 °C (dec.)(lit.)
- Boiling point:
- 450.7±45.0 °C(Predicted)
- Density
- 1.2556 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Aqueous Base (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- pka
- 2.22±0.10(Predicted)
- form
- crystalline
- color
- Almost white to beige
- CAS DataBase Reference
- 7730-20-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 17643
- Product name
- 6-fluoro-DL-Tryptophan
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17643
- Product name
- 6-fluoro-DL-Tryptophan
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 17643
- Product name
- 6-fluoro-DL-Tryptophan
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 17643
- Product name
- 6-fluoro-DL-Tryptophan
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $231
- Updated
- 2024/03/01
- Product number
- F401785
- Product name
- 6-Fluoro-DL-Tryptophan
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
6-FLUORO-DL-TRYPTOPHAN Chemical Properties,Usage,Production
Chemical Properties
almost white to beige powder
Definition
ChEBI: 6-Fluoro-DL-tryptophan is an indolyl carboxylic acid.
Biological Activity
6-fluoro-dl-tryptophan is a serotonin (5-ht) synthesis inhibitor.serotonin or 5-hydroxytryptamine (5-ht), a monoamine neurotransmitter, is biochemically derived from tryptophan. serotonin is primarily present in the gastrointestinal tract, blood platelets, and the central nervous system of animals. serotonin is considered to be a contributor to feelings of well-being and happiness.
in vitro
the potential competition was investigated between l-tryptophan (trp) and 6-fluoro-dl-tryptophan (6-f-trp). in equilibrium dialysis experiments, albumin bound about 80% of trp and 50% of 6-f-trp. competitive inhibition was assessed as the decrease in the apparent ka of trp in the presence of 6-f-trp, with no modification of the n value [1].
in vivo
rats werer administered 6-fluoro-dl-tryptophan (6f-trp) and its neurochemical effects on central catechole and indole were evaluated. results showed that neither norepinephrine nor dopamine and its major metabolites were affected by 6f-trp. with regard to serotonin (5-ht), 6f-trp could induce a transient depletion in all the studied brain areas, with a maximum of about 60-65% obtained between 1 and 3 hr. after 6 hr, 5-ht levels returned to control values. in addition, the 5-hydroxyindolacetic acid (5-hiaa) level was also reduced 3 hr after 6f-trp administration. a large dose-dependent increase in tryptophan was seen in the four brain areas, mainly due to an inhibition of tryptophan incorporation into protein, as demonstrated by experiments with mouse neuroblastoma cells [2].
References
[1] chanut, e. ,zini, r.,trouvin, j.h., et al. albumin binding and brain uptake of 6-fluoro-dl-tryptophan: competition with l-tryptophan. biochemical pharmacology 44(10), 2082-2085 (1992).
[2] chanut, e. ,trouvin, j.h.,bondoux, d., et al. metabolism of 6-fluoro-dl-tryptophan and its specific effects on the rat brain serotoninergic pathway. biochemical pharmacology 45(5), 1049-1057 (1992).
6-FLUORO-DL-TRYPTOPHAN Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-FLUORO-DL-TRYPTOPHAN manufacturers
- Product
- 6-FLUORO-DL-TRYPTOPHAN 7730-20-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 200kg
- Release date
- 2020-01-12