ChemicalBook > CAS DataBase List > EB-47

EB-47

Product Name
EB-47
CAS No.
366454-36-6
Chemical Name
EB-47
Synonyms
EB-47;EB-47, 10 mM in DMSO;EB 47 DIHYDROCHLORIDE;PARP Inhibitor IX, EB-47;Adenosine, 5'-deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxo-;5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)aMino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine Dihydrochloride;4-[1-(6-AMino-9H-purin-9-yl)-1-deoxy-β-D- ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetaMide Dihydrochloride
CBNumber
CB3769005
Molecular Formula
C24H27N9O6
Formula Weight
537.53
MOL File
Mol file
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EB-47 Property

Density 
1.83±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 10 mg/mL, soluble
form 
solid
pka
12.99±0.70(Predicted)
color 
white
Water Solubility 
water: 50mg/mL
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4140
Product name
EB47
Purity
≥99%(HPLC)
Packaging
10
Price
$265
Updated
2021/12/16
Tocris
Product number
4140
Product name
EB47
Purity
≥99%(HPLC)
Packaging
50
Price
$1092
Updated
2021/12/16
Usbiological
Product number
255216
Product name
EB 47
Packaging
10mg
Price
$531
Updated
2021/12/16
TRC
Product number
E320300
Product name
EB47
Packaging
10mg
Price
$1320
Updated
2021/12/16
ChemScene
Product number
CS-0003719
Product name
EB-47
Packaging
5mg
Price
$280
Updated
2021/12/16
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EB-47 Chemical Properties,Usage,Production

Uses

EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult.

Biological Activity

Cell permeable: yes', 'Primary Target
PARP-1', 'Product does not compete with ATP.', 'Reversible: no

in vivo

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].

IC 50

ARTD1/PARP1: 45 nM (IC50)

EB-47 Preparation Products And Raw materials

Raw materials

Preparation Products

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EB-47 Suppliers

Canada 1 China 26 Switzerland 1 United Kingdom 2 United States 9 Global 39
J & K SCIENTIFIC LTD.
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Energy Chemical
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366454-36-6, EB-47Related Search:


  • EB-47
  • 4-[1-(6-AMino-9H-purin-9-yl)-1-deoxy-β-D- ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetaMide Dihydrochloride
  • 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)aMino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine Dihydrochloride
  • EB 47 DIHYDROCHLORIDE
  • PARP Inhibitor IX, EB-47
  • Adenosine, 5'-deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxo-
  • EB-47, 10 mM in DMSO
  • 366454-36-6
  • C24H29N9O6Cl2
  • P to Q
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • PARP Poly(ADP-ribose) Polymerase
  • Biochemicals and Reagents
  • BioChemical
  • PARP Poly(ADP-ribose) Polymerase
  • Enzyme Inhibitors by Enzyme
  • P to