ChemicalBook > CAS DataBase List > 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE

4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE

Product Name: 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
CAS No.: 4233-33-4
Chemical Name: 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
Synonyms: PTAD;4-PHENYL-3;AURORA KA-3851;Mosapride Impurity 24;4-Phenyl-1,2,4-triazole-3,5-dione;4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE;4-phenyl-1,2,4-triazole-3,5-quinone;4-Phenyl-1,2,3-triazoline-3,5-dione;4-Phenyl-4H-1,2,4-triazole-3,5-dione;4-PHENYL-3H-1,2,4-TRIAZOLINE-3,5-DIONE
CBNumber: CB3769656
Molecular Formula: C8H5N3O2
Formula Weight: 175.14
MOL File: 4233-33-4.mol

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4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Property

Melting point:: 165-170 °C (dec.)(lit.)
Boiling point:: 263.8±23.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: -1.71±0.20(Predicted)
form: Solid
color: Red to Dark Red
BRN: 141548
InChI: InChI=1S/C8H5N3O2/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H
InChIKey: ISULLEUFOQSBGY-UHFFFAOYSA-N
SMILES: N1C(=O)N(C2=CC=CC=C2)C(=O)N=1
CAS DataBase Reference: 4233-33-4(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 280992
Product name: 4-Phenyl-1,2,4-triazoline-3,5-dione
Purity: 97%
Packaging: 1g
Price: $110
Updated: 2025/07/31

Sigma-Aldrich

Product number: 280992
Product name: 4-Phenyl-1,2,4-triazoline-3,5-dione
Purity: 97%
Packaging: 5g
Price: $336
Updated: 2025/07/31

TCI Chemical

Product number: P1184
Product name: 4-Phenyl-1,2,4-triazoline-3,5-dione
Packaging: 1g
Price: $108
Updated: 2025/07/31

TCI Chemical

Product number: P1184
Product name: 4-Phenyl-1,2,4-triazoline-3,5-dione
Packaging: 5g
Price: $367
Updated: 2025/07/31

TCI Chemical

Product number: P1184
Product name: 4-Phenyl-1,2,4-triazoline-3,5-dione
Packaging: 25g
Price: $964
Updated: 2025/07/31

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4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Chemical Properties,Usage,Production

Chemical Properties

4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE is Red Solid

Uses

4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE is used in the methods for determining levels of 1,25 dihydroxyvitamin d2 and d3 in biological and food samples and dietary supplements.

Uses

4-Phenyl-1,2,4-triazoline-3,5-dione (PTAD) can be used as an efficient and selective reagent for the oxidation of thiols to disulfides.
It can also be used:???????

As a dehydrogenating agent to synthesize annulated dihydropyridazines by inverse [4+2] cycloaddition reaction between cyclic alkenes and 1,2,4,5-tetrazines.???????
As a dienophile to synthesize cycloaddition products by fast hetero-Diels?Alder reactions.???????
As an efficient oxidizing agent for the synthesis of pyridine derivatives from 1,4-dihydropyridines.
In the synthesis of urazoles via [3+2] cycloaddition with allylsilanes.

Uses

4-Phenyl-1,2,4-triazoline-3,5-dione may be used as a derivatizing reagent for the determination of trace levels of 25-hydroxyvitamin D and its C-3 epimer in biological samples and cholecalciferol (vitamin D₃) in fortified infant formula, milk and milk powder using liquid chromatography–tandem mass spectrometry (LC–MS/MS)technique.

Synthesis Reference(s)

Synthetic Communications, 17, p. 409, 1987 DOI: 10.1080/00397918708063918

General Description

4-Phenyl-1,2,4-triazoline-3,5-dione, also known as Cookson reagent, is a strong dienophile, which gives a stable Diels-Alder adduct quantitatively within a short time and under mild conditions. It is commonly used as a protecting group of the diene moiety for the synthesis of vitamin D₃ (VD₃)-related compounds.

Purification Methods

PTAD forms carmine red needles by sublimation (ice cold finger) at 100o/0.1mm, and/or by recrystallisation from EtOH. IR: 1760 and 1780 cm-1 . [Cookson et al. Org Synth 51 121 1971, Moore max et al. J Org Chem 39 3700 1974, Beilstein 26 I 57, 26 III/IV 540.]

4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Mosapride Impurity 24
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-12

Shaanxi Dideu Medichem Co. Ltd

Product: 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE 4233-33-4
Price: US $20.00-100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-15

Career Henan Chemical Co

Product: 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE 4233-33-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customise
Release date: 2018-08-09

4233-33-4, 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONERelated Search:

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Oxazoline 4-(4-(6-methoxy-2-benzoxazolyl)phenyl)-1,2,4-triazoline-3,5-dione 4-(4-CHLORO-PHENYL)-[1,2,4]TRIAZOLE-3,5-DIONE 4-P-TOLYL-[1,2,4]TRIAZOLE-3,5-DIONE 4-(4-FLUORO-PHENYL)-[1,2,4]TRIAZOLE-3,5-DIONE 4-(2-CHLORO-PHENYL)-[1,2,4]TRIAZOLE-3,5-DIONE 4-(4-METHOXY-PHENYL)-[1,2,4]TRIAZOLE-3,5-DIONE 4-(4-BROMO-PHENYL)-[1,2,4]TRIAZOLE-3,5-DIONE 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE

AURORA KA-3851

4-PHENYL-3H-1,2,4-TRIAZOLINE-3,5-DIONE

4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE

4-PHENYL-3,5-DIHYDRO-4ETA-1,2,4-TRIAZOLE-3,5-DIONE

PTAD

4-Phenyl-1,2,4-triazole-3,5-dione

3H-1,2,4-Triazole-3,5(4H)-dione, 4-phenyl-

3,5-DIHYDRO-4-PHENYL-4H-1,2,4-TRIAZOLE-3,5-DIONE 97+%

4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, PTAD

4-Phenyl-3,5-dihydro-4H-1,2,4-triazole-3,5-dione

4-Phenyl-4H-1,2,4-triazole-3,5-dione

4-phenyl-1,2,4-triazole-3,5-quinone

4-Phenyl-1,2,3-triazoline-3,5-dione

3,5-DIHYDRO-4-PHENYL-4H-1,2,4-TRIAZOLE-3

3,5-DIHYDRO-4-PHENYL-4ETA-1,2,4-TRIAZOLE-3,5-DIONE

3,5-DIHYDRO-4-PHENYL-4H-1,2,4-TRIAZOLE-3,5-DIONE

4-Phenyl-1,2,4-triazoline-3,5-dione 97%

3,5-Dihydro-4-phenyl-4H-1,2,4-triazole-3,5-dione for synthesis

4-PHENYL-3

Mosapride Impurity 24

4233-33-4

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Triazoles

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