4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
- Product Name
- 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
- CAS No.
- 4233-33-4
- Chemical Name
- 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE
- Synonyms
- PTAD;4-PHENYL-3;AURORA KA-3851;Mosapride Impurity 24;4-Phenyl-1,2,4-triazole-3,5-dione;4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE;4-phenyl-1,2,4-triazole-3,5-quinone;4-Phenyl-1,2,3-triazoline-3,5-dione;4-Phenyl-4H-1,2,4-triazole-3,5-dione;4-PHENYL-3H-1,2,4-TRIAZOLINE-3,5-DIONE
- CBNumber
- CB3769656
- Molecular Formula
- C8H5N3O2
- Formula Weight
- 175.14
- MOL File
- 4233-33-4.mol
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Property
- Melting point:
- 165-170 °C (dec.)(lit.)
- Boiling point:
- 263.8±23.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- -1.71±0.20(Predicted)
- form
- Solid
- color
- Red to Dark Red
- BRN
- 141548
- InChIKey
- ISULLEUFOQSBGY-UHFFFAOYSA-N
- CAS DataBase Reference
- 4233-33-4(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 280992
- Product name
- 4-Phenyl-1,2,4-triazoline-3,5-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 280992
- Product name
- 4-Phenyl-1,2,4-triazoline-3,5-dione
- Purity
- 97%
- Packaging
- 5g
- Price
- $326
- Updated
- 2024/03/01
- Product number
- P1184
- Product name
- 4-Phenyl-1,2,4-triazoline-3,5-dione
- Packaging
- 1g
- Price
- $108
- Updated
- 2024/03/01
- Product number
- P1184
- Product name
- 4-Phenyl-1,2,4-triazoline-3,5-dione
- Packaging
- 5g
- Price
- $367
- Updated
- 2024/03/01
- Product number
- P1184
- Product name
- 4-Phenyl-1,2,4-triazoline-3,5-dione
- Packaging
- 25g
- Price
- $964
- Updated
- 2024/03/01
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Chemical Properties,Usage,Production
Chemical Properties
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE is Red Solid
Uses
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE is used in the methods for determining levels of 1,25 dihydroxyvitamin d2 and d3 in biological and food samples and dietary supplements.
Uses
4-Phenyl-1,2,4-triazoline-3,5-dione (PTAD) can be used as an efficient and selective reagent for the oxidation of thiols to disulfides.
It can also be used:???????
- As a dehydrogenating agent to synthesize annulated dihydropyridazines by inverse [4+2] cycloaddition reaction between cyclic alkenes and 1,2,4,5-tetrazines.???????
- As a dienophile to synthesize cycloaddition products by fast hetero-Diels?Alder reactions.???????
- As an efficient oxidizing agent for the synthesis of pyridine derivatives from 1,4-dihydropyridines.
- In the synthesis of urazoles via [3+2] cycloaddition with allylsilanes.
Uses
4-Phenyl-1,2,4-triazoline-3,5-dione may be used as a derivatizing reagent for the determination of trace levels of 25-hydroxyvitamin D and its C-3 epimer in biological samples and cholecalciferol (vitamin D3) in fortified infant formula, milk and milk powder using liquid chromatography–tandem mass spectrometry (LC–MS/MS)technique.
Synthesis Reference(s)
Synthetic Communications, 17, p. 409, 1987 DOI: 10.1080/00397918708063918
General Description
4-Phenyl-1,2,4-triazoline-3,5-dione, also known as Cookson reagent, is a strong dienophile, which gives a stable Diels-Alder adduct quantitatively within a short time and under mild conditions. It is commonly used as a protecting group of the diene moiety for the synthesis of vitamin D3 (VD3)-related compounds.
Purification Methods
PTAD forms carmine red needles by sublimation (ice cold finger) at 100o/0.1mm, and/or by recrystallisation from EtOH. IR: 1760 and 1780 cm-1 . [Cookson et al. Org Synth 51 121 1971, Moore max et al. J Org Chem 39 3700 1974, Beilstein 26 I 57, 26 III/IV 540.]
4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE manufacturers
- Product
- Mosapride Impurity 24
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-12
- Product
- 4-PHENYL-1,2,4-TRIAZOLINE-3,5-DIONE 4233-33-4
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customise
- Release date
- 2018-08-09