2,3,5,6-Tetrafluoroaniline
Uses- Product Name
- 2,3,5,6-Tetrafluoroaniline
- CAS No.
- 700-17-4
- Chemical Name
- 2,3,5,6-Tetrafluoroaniline
- Synonyms
- 2,3,5,6-TETRAFLUOROBENZENAMINE;Tetrafluoroaniline3;Tetrafluorobenzenamine;2,3,5,6-Tetrafluoraniline;2,3,5,6-TETRAFLUOROANILINE;Aniline, 2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoroaniline98%;2,3,5,6-Tetrafluoroaniline 98%;Benzenamine, 2,3,5,6-tetrafluoro-;1-Amino-2,3,5,6-tetrafluorobenzene
- CBNumber
- CB3774775
- Molecular Formula
- C6H3F4N
- Formula Weight
- 165.09
- MOL File
- 700-17-4.mol
2,3,5,6-Tetrafluoroaniline Property
- Melting point:
- 31-32 °C(lit.)
- Boiling point:
- 158 °C(lit.)
- Density
- 1,744 g/cm3
- Flash point:
- 145 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- perchloric acid: soluble
- pka
- -0.22±0.10(Predicted)
- form
- powder to lump to clear liquid
- color
- White or Colorless to Light orange to Yellow
- BRN
- 2211579
- InChI
- InChI=1S/C6H3F4N/c7-2-1-3(8)5(10)6(11)4(2)9/h1H,11H2
- InChIKey
- SPSWJTZNOXMMMV-UHFFFAOYSA-N
- SMILES
- C1(N)=C(F)C(F)=CC(F)=C1F
- CAS DataBase Reference
- 700-17-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,3,5,6-Tetrafluoroaniline(700-17-4)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-36
- RIDADR
- 2941
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T1028
- Product name
- 2,3,5,6-Tetrafluoroaniline
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- T1028
- Product name
- 2,3,5,6-Tetrafluoroaniline
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $145
- Updated
- 2025/07/31
- Product number
- T311005
- Product name
- 2,3,5,6-Tetrafluoroaniline
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0017300
- Product name
- 2,3,5,6-TETRAFLUOROANILINE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1147.19
- Updated
- 2021/12/16
- Product number
- 1137CA
- Product name
- 2,3,5,6-Tetrafluoroaniline
- Packaging
- 100g
- Price
- $352
- Updated
- 2021/12/16
2,3,5,6-Tetrafluoroaniline Chemical Properties,Usage,Production
Uses
2,3,5,6-Tetrafluoroaniline is a white solid and an important pharmaceutical and pesticide intermediate. It can be used as a raw material to synthesize a variety of drugs that are effective in treating inflammation and depression, and has good pharmaceutical effects.
Chemical Properties
WHITE CRYSTALLINE MASS
Synthesis
17823-38-0
700-17-4
The general procedure for the synthesis of 2,3,5,6-tetrafluoroaniline from 4-amino-2,3,5,6-tetrafluorobenzonitrile was as follows: 867.6 grams of sulfuric acid with a mass fraction of 90% was added to the reactor, and the temperature was raised to 100°C. The reaction was carried out at a uniform rate. Under stirring, 482 g of 4-amino-2,3,5,6-tetrafluorobenzonitrile was added at a uniform rate, and the addition process was controlled to be completed within 2 hours. After the addition was completed, the reaction temperature was maintained at 100 °C to continue the reaction for 3 hours. Subsequently, 165 g of water was added to the reaction system, the sulfuric acid concentration was diluted to 80%, and the reaction temperature was raised to 120 °C and maintained at this temperature for 10 hours. After that, the reaction temperature was further increased to 130°C and the reaction was continued for 5 hours. Upon completion of the reaction, the reaction system was cooled to room temperature. Under the cooling condition, 300 g of water was added to the reaction system, and then 1715 g of 45% aqueous sodium hydroxide solution was slowly added dropwise for neutralization until the pH reached 9. After the neutralization was completed, the temperature was raised for distillation, and ultimately, 410 g of a white solid product 2,3,5,6-tetrafluoroaniline was obtained with a purity of 99.8% and a yield of 98%.
References
[1] Patent: CN107915647, 2018, A. Location in patent: Paragraph 0024; 0026; 0027; 0029
[2] C. A., 1968, vol. 69, p. 35787
[3] , Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84,
2,3,5,6-Tetrafluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3,5,6-Tetrafluoroaniline manufacturers
- Product
- 2,3,5,6-Tetrafluoroaniline 700-17-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-10
- Product
- 2,3,5,6-Tetrafluoroaniline 700-17-4
- Price
- US $35.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-17
- Product
- 2,3,5,6-Tetrafluoroaniline; 2,3,5,6-Tetrafluorobenzenamine; Tetrafluoroaniline; Tetrafluorobenzenamine 700-17-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10mt
- Release date
- 2020-03-25