ILOPROST
- Product Name
- ILOPROST
- CAS No.
- 78919-13-8
- Chemical Name
- ILOPROST
- Synonyms
- zk36374;LLOPROST;Ilomedin;Endoprost;CILOPROST;Iloprost Na;iloprostaglandin;Iloprost (Ciloprost;1h)-pentalenylidene)-;(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2)
- CBNumber
- CB3775439
- Molecular Formula
- C22H32O4
- Formula Weight
- 360.49
- MOL File
- 78919-13-8.mol
ILOPROST Property
- Boiling point:
- 539.2±50.0 °C(Predicted)
- Density
- 1.210±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in methyl acetate
- form
- film
- pka
- 4.77±0.10(Predicted)
- color
- colorless
- Stability:
- Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H311Toxic in contact with skin
H331Toxic if inhaled
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- SML1651
- Product name
- Iloprost
- Purity
- ≥98% (HPLC)
- Packaging
- 1MG
- Price
- $134
- Updated
- 2024/03/01
- Product number
- SML1651
- Product name
- Iloprost
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $543
- Updated
- 2024/03/01
- Product number
- 18215
- Product name
- Iloprost
- Purity
- ≥97%
- Packaging
- 500μg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 18215
- Product name
- Iloprost
- Purity
- ≥97%
- Packaging
- 1mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- 18215
- Product name
- Iloprost
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $1010
- Updated
- 2024/03/01
ILOPROST Chemical Properties,Usage,Production
Description
Iloprost is a stable epoprostenol derivative which acts as an inhibitor of platelet aggregation and is recommended for the treatment of peripheral vascular diseases. The compound was shown to be a potent agonist at PGE2-sensitive and prostacyclin-sensitive receptors in animal studies. Iloprost is administered by IV infusion and has been reported to have beneficial effects in Buerger's and Raynaud's diseases as well as peripheral artery occlusive disease.
Chemical Properties
Colourless Oil
Chemical Properties
Quinone exists as a large, yellow, monoclinic prism with an irritating odor. Quinone is extensively used in the dye, textile, chemical, tanning, and cosmetic industries. In chemical synthesis for hydroquinone and other chemicals, quinone is used as an intermediate. It is also used in the manufacturing industries and chemical laboratories associated with protein fi ber, photographic fi lm, hydrogen peroxide, and gelatin making.
Originator
Schering AG (Germany)
Uses
A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud''s phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
Definition
ChEBI: A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R /stereo>)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.
brand name
Ventavis (Schering);Iiomedin.
Health Hazard
Exposures to quinine vapor are highly irritating to the eyes and may be followed by corneal opacities, structural changes in the cornea, and loss of vision. Solid quinone may produce discoloration, severe irritation, swelling, and form papules and vesicles.
Biological Activity
Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).
Biochem/physiol Actions
Iloprost is used to treat children with PH (pulmonary hypertension) after the surgery to clear CHD (congenital heart disease). In transplant patients, this prostacyclin analogue is used to inhibit renal dysfunction. Iloprost performs various functions like vasodilatation and cytoprotection. It has higher stability than prostacyclin.
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View Lastest Price from ILOPROST manufacturers
- Product
- ILOPROST 78919-13-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-07-09