2-Methylthiazole-4-carboxamide

Product Name: 2-Methylthiazole-4-carboxamide
CAS No.: 31825-95-3
Chemical Name: 2-Methylthiazole-4-carboxamide
Synonyms: 2-Methyl-4-thiazolecarboxamide;4-THIAZOLECARBOXAMIDE, 2-METHYL-;2-Methyl-1,3-oxazole-4-carboamide
CBNumber: CB3776092
Molecular Formula: C5H6N2OS
Formula Weight: 142.18
MOL File: 31825-95-3.mol

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2-Methylthiazole-4-carboxamide Property

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

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Safety

Hazard Note: Harmful
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M331740
Product name: 2-Methylthiazole-4-carboxamide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Ark Pharm

Product number: P000724685
Product name: 2-Methylthiazole-4-carboxamide
Purity: 97%
Packaging: 100mg
Price: $54
Updated: 2021/12/16

Ark Pharm

Product number: P000724685
Product name: 2-Methylthiazole-4-carboxamide
Purity: 97%
Packaging: 250mg
Price: $81
Updated: 2021/12/16

Apolloscientific

Product number: OR29665
Product name: 2-Methyl-1,3-thiazole-4-carboxamide
Packaging: 250mg
Price: $86
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H48-1-X2
Product name: 2-Methyl-1,3-thiazole-4-carboxamide
Packaging: 250mg
Price: $95
Updated: 2021/12/16

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2-Methylthiazole-4-carboxamide Chemical Properties,Usage,Production

Uses

2-Methylthiazole-4-carboxamide is a useful reactant for the synthesis of bisthiazole-?based histone deacetylase inhibitors.

Synthesis

6436-59-5

31825-95-3

Step 1. Synthesis of 2-methylthiazole-4-carboxamide (Compound 2A) Ethyl 2-methylthiazole-4-carboxylate (Compound 1, 0.8 g, 4.68 mmol) was mixed with an ethanol solution of ammonia (NH3/EtOH, 10 mL) and the reaction was stirred at 60 °C for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=1:1) to afford 2-methylthiazole-4-carboxamide (Compound 2, 0.44 g, 77% yield) as a white solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[2] Patent: WO2011/106414, 2011, A1. Location in patent: Page/Page column 83
[3] Journal of the Chemical Society, 1946, p. 91
[4] Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5750 - 5753
[5] Journal of the American Chemical Society, 2011, vol. 133, # 15, p. 5900 - 5904

2-Methylthiazole-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methylthiazole-4-carboxamide Suppliers

China 30 India 4 United Kingdom 3 United States 10 Global 47

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31825-95-3, 2-Methylthiazole-4-carboxamideRelated Search:

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4-THIAZOLECARBOXAMIDE, 2-METHYL-

2-Methyl-4-thiazolecarboxamide

2-Methyl-1,3-oxazole-4-carboamide

31825-95-3