ChemicalBook > CAS DataBase List > JAK3 INHIBITOR VI
JAK3 INHIBITOR VI
- Product Name
- JAK3 INHIBITOR VI
- CAS No.
- 856436-16-3
- Chemical Name
- JAK3 INHIBITOR VI
- Synonyms
- JI6;JAK3 INHIBITOR VI
- CBNumber
- CB3787012
- Molecular Formula
- C19H17N3O4S
- Formula Weight
- 383.42098
- MOL File
- 856436-16-3.mol
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JAK3 INHIBITOR VI Property
- storage temp.
- +2C to +8C
- form
- Yellow solid
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 420126
- Product name
- JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem
- Packaging
- 5MG
- Price
- $195
- Updated
- 2023/06/20
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JAK3 INHIBITOR VI Chemical Properties,Usage,Production
General Description
A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
Biochem/physiol Actions
Cell permeable: yes
JAK3 INHIBITOR VI Preparation Products And Raw materials
Raw materials
Preparation Products
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