4-AMINO-2-CHLOROQUINOLINE
- Product Name
- 4-AMINO-2-CHLOROQUINOLINE
- CAS No.
- 80947-25-7
- Chemical Name
- 4-AMINO-2-CHLOROQUINOLINE
- Synonyms
- 2-Chloro-4-quinolinamine;2-Chloroquinolin-4-amine;4-Quinolinamine,2-chloro-;4-AMINO-2-CHLOROQUINOLINE;(2-Chloroquinolin-4-yl)amine
- CBNumber
- CB3789061
- Molecular Formula
- C9H7ClN2
- Formula Weight
- 178.62
- MOL File
- 80947-25-7.mol
4-AMINO-2-CHLOROQUINOLINE Property
- Melting point:
- 250℃
- Boiling point:
- 366℃
- Density
- 1.363
- Flash point:
- 175℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.24±0.50(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C9H7ClN2/c10-9-5-7(11)6-3-1-2-4-8(6)12-9/h1-5H,(H2,11,12)
- InChIKey
- QVCRGJALYOLXDC-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C(N)=CC=1Cl
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C381865
- Product name
- 2-Chloroquinolin-4-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC142337
- Product name
- 2-Chloroquinolin-4-amine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC142337
- Product name
- 2-Chloroquinolin-4-amine
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z5149
- Product name
- 2-Chloroquinolin-4-amine
- Packaging
- 1g
- Price
- $143
- Updated
- 2021/12/16
- Product number
- FC142337
- Product name
- 2-Chloroquinolin-4-amine
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
4-AMINO-2-CHLOROQUINOLINE Chemical Properties,Usage,Production
Synthesis
703-61-7
80947-25-7
The general procedure for the synthesis of 4-amino-2-chloroquinoline from 2,4-dichloroquinoline is as follows: the synthesis of compound 9 has been reported in the literature [von Btichi, J. et al. Die Tuberkulostatische Wirkung von 2-Oxy-4-amino-chinolin Derivaten. Helv. Chim. Acta. 1949, 32, 1806-1814; Wojahn, H. Untersuchungen ber den Zusammenhang von chemischer Konstitution und anasthesierender Wirkung bei 2- Alkoxy-chinolin Derivaten. Arch. Pharm. 1936, 274, 83-106]. However, in the present experiments, compound 9 was prepared by the following method. the brief procedure was as follows: compound 8 (0.35 g, 1.8 mmol) was suspended in 28-30% aqueous ammonia solution (3 mL). The reaction was carried out in a microwave reactor at 160 °C for 2.5 hours. Upon completion of the reaction, the ammonia was removed by evaporation. The product was purified by column chromatography using dichloromethane solution containing 3% methanol as eluent. Yield: 0.14 g (44%).1H NMR (CDCl3) δ 4.83 (broad single peak, 2H, NH2), 6.62 (single peak, 1H, aromatics), 7.43-7.51 (multiple peaks, 1H, aromatics), 7.63-7.73 (multiple peaks, 2H, aromatics), 7.89-7.95 (multiple peaks, 1H, aromatics).13C NMR ( 600 MHz, CDCl3) δ 103.07, 117.60, 120.08, 125.27, 129.13, 130.46, 148.26, 151.40, 151.41.
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 4, p. 926 - 931
[2] Patent: WO2010/20981, 2010, A1. Location in patent: Page/Page column 30; 2/2
[3] Journal of Photochemistry and Photobiology A: Chemistry, 2017, vol. 332, p. 72 - 86
4-AMINO-2-CHLOROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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