3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- Product Name
- 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- CAS No.
- 294675-79-9
- Chemical Name
- 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- Synonyms
- ERK INHIBITOR;2,4-Thiazolidinedione, 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-;3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- CBNumber
- CB3797565
- Molecular Formula
- C14H16N2O3S
- Formula Weight
- 292.35
- MOL File
- Mol file
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥4mg/mL
- form
- powder
- color
- off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A6355
- Product name
- 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- CHM0116130
- Product name
- 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $698.52
- Updated
- 2021/12/16
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries.
Biochem/physiol Actions
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2.
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91