[2H5]-Quinapril

Product Name: [2H5]-Quinapril
CAS No.: 1279029-79-6
Chemical Name: [2H5]-Quinapril
Synonyms: [2H5]-Quinapril;2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenyl-d5-propyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid;Quinapril D5Q: What is Quinapril D5 Q: What is the CAS Number of Quinapril D5 Q: What is the storage condition of Quinapril D5 Q: What are the applications of Quinapril D5
CBNumber: CB38011283
Molecular Formula: C25H30N2O5
Formula Weight: 438.52
MOL File: 1279029-79-6.mol

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[2H5]-Quinapril Property

storage temp.: -20°C
solubility: Methanol: soluble
form: A solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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[2H5]-Quinapril Chemical Properties,Usage,Production

Uses

Quinapril-d5 is the deuterium labeled Quinapril[1].

Biological Activity

Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat.1,2 In vivo, quinapril (3 mg/kg) reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats.2 It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (10-200 mg/kg) prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.

References

1.Vago, T., Bevilacqua, M., Conci, F., et al.Angiotensin converting enzyme binding sites in human heart and lung: Comparison with rat tissuesBr. J. Pharmacol.107(3)821-825(1992) 2.Kaplan, H.R., Taylor, D.G., and Olson, S.C.Quinapril: Overview of preclinical dataClin. Cardiol.13(6 Suppl. 7)VII6-VII12(1990)

[2H5]-Quinapril Preparation Products And Raw materials

Raw materials

Preparation Products

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[2H5]-Quinapril Suppliers

China 10 India 1 United States 1 Global 12

ChemeGen

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1279029-79-6, [2H5]-QuinaprilRelated Search:

IBBLRJGOOANPTQ-GOMJJGCLSA-N Quinaprilat-D5 QUINAPRILAT HYDRATE

[2H5]-Quinapril

Quinapril D5Q: What is Quinapril D5 Q: What is the CAS Number of Quinapril D5 Q: What is the storage condition of Quinapril D5 Q: What are the applications of Quinapril D5

2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenyl-d5-propyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

1279029-79-6