G6PD activator AG1
- Product Name
- G6PD activator AG1
- CAS No.
- 421581-52-4
- Chemical Name
- G6PD activator AG1
- Synonyms
- G6PD activator AG1;G-6PD activator AG1,G6PD activator AG1;1H-Indole-3-ethanamine, N,N′-(dithiodi-2,1-ethanediyl)bis-;2,2'-disulfanediylbis(N-(2-(1H-indol-3-yl)ethyl)ethan-1-amine);2,2'-disulfanediylbis(N-(2-(1H-indol-3-yl)ethyl)ethan-1-amine);1H-Indole-3-ethanamine, N,N'-(dithiodi-2,1-ethanediyl)bis- (9CI)
- CBNumber
- CB38054408
- Molecular Formula
- C24H30N4S2
- Formula Weight
- 438.65
- MOL File
- 421581-52-4.mol
G6PD activator AG1 Property
- Boiling point:
- 689.8±55.0 °C(Predicted)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMSO: 20.83 mg/mL (47.49 mM)
- form
- Oil
- pka
- 16.93±0.30(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C24H30N4S2/c1-3-7-23-21(5-1)19(17-27-23)9-11-25-13-15-29-30-16-14-26-12-10-20-18-28-24-8-4-2-6-22(20)24/h1-8,17-18,25-28H,9-16H2
- InChIKey
- AJBHTYKMNQDUAA-UHFFFAOYSA-N
- SMILES
- C(C1=CNC2=CC=CC=C21)CNCCSSCCNCCC1=CNC2=CC=CC=C12
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 006235
- Product name
- G6PDactivatorAG1
- Packaging
- 004
- Price
- $580
- Updated
- 2021/12/16
G6PD activator AG1 Chemical Properties,Usage,Production
Uses
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes[1][2].
Definition
ChEBI: N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[2-(1H-indol-3-yl)ethan-1-amine] is an organic disulfide composed of two molecules of 2-{[2-(1H-indol-3-yl)ethyl]amino}ethane-1-thiol linked together via a disulfide bond. It is a glucose-6-phosphate dehydrogenase (G6PD) activator which reduces oxidative stress in cells and zebrafish. It is an organic disulfide, a member of indoles and a secondary amino compound.
References
[1] https://patents.google.com/patent/WO2019023264A1/enoq=WO2019023264A1
[2] Kaitlyn Ryan, et al. Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency. Pharmacol Ther. 2020 Dec 14;222:107788. DOI:10.1016/j.pharmthera.2020.107788
G6PD activator AG1 Preparation Products And Raw materials
Raw materials
Preparation Products
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