ERD-308

Product Name: ERD-308
CAS No.: 2320561-35-9
Chemical Name: ERD-308
Synonyms: ERD-308;CID 138454799;(2S,4R)-1-[(2S)-2-[2-({5-[ethyl(2-{4-[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophene-3-carbonyl]phenoxy}ethyl)amino]pentyl}oxy)acetamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
CBNumber: CB38054589
Molecular Formula: C55H65N5O9S2
Formula Weight: 1004.27
MOL File: 2320561-35-9.mol

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ERD-308 Property

Boiling point:: 1173.0±65.0 °C(Predicted)
Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO:50.0(Max Conc. mg/mL);49.79(Max Conc. mM)
pka: 8.83±0.15(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: 027684
Product name: ERD-308
Packaging: 001
Price: $1300
Updated: 2021/12/16

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ERD-308 Chemical Properties,Usage,Production

Description

ERD-308 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER) ERD-308 achieves DC50_x000D_ (concentration causing 50% of protein degradation) values of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively, and induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines. Significantly, ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells.

in vitro

ERD-308 achieves DC50 (concentration causing 50% of protein degradation) values of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively, and induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines. Significantly, ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells._x000D_ _x000D_ Reference: J Med Chem. 2019 Feb 14;62(3):1420-1442. https://pubmed.ncbi.nlm.nih.gov/30990042/

target

ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment.

ERD-308 Preparation Products And Raw materials

Raw materials

Preparation Products

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ERD-308 Suppliers

China 19 United States 2 Global 21

Sichuan Wei Keqi Biological Technology Co., Ltd.

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2320561-35-9, ERD-308Related Search:

ERD-308

(2S,4R)-1-[(2S)-2-[2-({5-[ethyl(2-{4-[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophene-3-carbonyl]phenoxy}ethyl)amino]pentyl}oxy)acetamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

CID 138454799

2320561-35-9